SpeF leader

SpeF is a putative cis-acting element identified in several gram negative alpha proteobacteria. It is proposed to be involved in regulating expression of genes involved in polyamide biosynthesis.

speF leader
Predicted secondary structure and sequence conservation of speF
Identifiers
SymbolspeF
RfamRF00518
Other data
RNA typeCis-reg; leader
Domain(s)Bacteria
SO0005836
PDB structuresPDBe

SpeF is one of five putative regulatory elements identified by a computational screen of Agrobacterium tumefaciens and other alpha-proteobacterial genomes for conserved sequence motifs in operon leaders.[1] In the majority of species analysed it is located in the leader of an operon containing the speF gene an ornithine decarboxylase enzyme that catalyses one of the first steps in polyamine biosynthesis. However, the authors did not detect binding of metabolites related to this pathway (L-ornithine, L-lysine, meso-diaminopimelate, putrescine, cadaverine, or spermidine) to the SpeF leader.[1]

Other non-coding RNAs uncovered in the same analysis include: suhB, ybhL, metA and serC.[1]

References
  1. Corbino KA, Barrick JE, Lim J, et al. (2005). "Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria". Genome Biol. 6 (8): R70. doi:10.1186/gb-2005-6-8-r70. PMC 1273637. PMID 16086852.
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