Shane Crotty

Shane Crotty is a virologist and professor in the Vaccine Discovery Division at La Jolla Institute for Immunology.[1]

Education and academic posts

Crotty completed B.S. degrees in Biology and Writing from Massachusetts Institute of Technology in 1996.[1] He then completed his Ph.D. in 2001 at the University of California, San Francisco with Raul Andino discovering the mechanism of action of the Hepatitis C drug ribavirin.[2][1]

Crotty went on to a postdoctoral fellowship from 2001 to 2003 with Rafi Ahmed at Emory University Vaccine Center studying immunity to viruses.[1] He joined La Jolla Institute for Allergy and Immunology (LIAI) in 2003, as well as the Department of Medicine of University of California, San Diego in 2004 as an Adjunct Assistant Professor. He became an Associate Member with tenure at LIAI in 2009,[3] and then a Professor with tenure.

Research

Crotty's research has focused on immune responses to viral infections, in particular those driven by vaccines. His lab has done major work on the regulation and proliferation of follicular helper T cells, as well as immunological protection from HIV infection and HIV vaccine delivery strategy.[4] [5]

Major publications
  • Choi Y, Kageyama R... Crotty S (2011). ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity. 34(6): pgs. 932-946
  • Johnston RJ, Poholek AC... Crotty S (2009). Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science. 325(5943): pgs. 1006-1010
  • Crotty S, Felgner P... Ahmed R (2003). Cutting edge: long-term B cell memory in humans after smallpox vaccination. Journal of Immunology. 171(10): pgs. 4969-4973
  • Crotty S, Cameron CE, Andino R (2001). RNA virus error catastrophe: Direct molecular test by using ribavirin. Proceedings of the National Academy of Sciences. 98(12): pgs. 6895-6900
  • Crotty S, Maag D... Cameron CE (2000). The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine. 6(12): pgs. 1375-1379

Other publications

Crotty is also the author of a biography of David Baltimore entitled Ahead of the Curve.[6][7]

References
  1. "Crotty Lab - Lab Members". La Jolla Institute. Retrieved 11 July 2019.
  2. "Shane Crotty". Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery. Retrieved 11 July 2019.
  3. Crotty, Shane. "Biographical Sketch" (PDF).
  4. "Crotty Lab". La Jolla Institute for Immunology.
  5. "New HIV vaccine strategy 'pumps' the immune system". Science Daily. May 9, 2019.
  6. Didier Trono (July 2001). "Ahead of the Curve: David Baltimore's Life in Science". Nature Medicine. doi:10.1038/89868.
  7. Barbara J. Culliton (2003). "Ahead of the Curve: David Baltimore's Life in Science (review)". Bulletin of the History of Medicine. 77 (2): 474–475. doi:10.1353/bhm.2003.0056.
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