Serrate RNA effector molecule homolog

SRRT
Identifiers
Aliases	SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDs	OMIM: 614469 MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	100,888,664 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	137,307,674 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding; • nucleic acid binding; • RNA binding;
Cellular component	• cytoplasm; • cell nucleus; • nucleoplasm; • protein complex; • macromolecular complex;
Biological process	• positive regulation of neurogenesis; • gene silencing by RNA; • cellular proliferation; • regulation of transcription, DNA-templated; • response to arsenic-containing substance; • transcription, DNA-templated; • neuronal stem cell population maintenance; • primary miRNA processing; • mRNA splicing, via spliceosome; • snRNA transcription from RNA polymerase II promoter; • mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	51593
	83701
	ENSG00000087087
	ENSMUSG00000037364
	Q9BXP5
	Q99MR6
	NM_001128852; NM_001128853; NM_001128854; NM_015908; NM_182800
	NM_001109909; NM_001109910; NM_031405; NM_001359602
	NP_001122324; NP_001122325; NP_001122326; NP_056992
	NP_001103379; NP_001103380; NP_113582; NP_001346531
	Wikidata
View/Edit Human	View/Edit Mouse

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.[5]

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.

References

GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: ARS2 ARS2 protein".

Rossman TG, Wang Z (1999). "Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis". Carcinogenesis. 20 (2): 311–6. doi:10.1093/carcin/20.2.311. PMID 10069470.
Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARS2 ARS2 protein".

Serrate RNA effector molecule homolog

References

Further reading