Septum (cell biology)

A septum in cell biology is the new cell wall that forms between two daughter cells as a result of cell division.[1]

Septins in Saccharomyces cerevisiae (fluorescent micrograph)
• Green: septins (AgSEP7-GFP)
• Red: cell outline (phase contrast)
• Scale bar: 10 μm

In yeast, septins form a ring structure, to which other proteins are recruited.[2] In particular, chitinase 2 is required, an enzyme that synthesises chitin thereby building up the primary septum. A secondary septum of β-glucans and mannoproteins is then assembled using the enzyme 1,3-Beta-glucan synthase, and the primary septum degraded during cell separation. After degradation of the primary septum, a chitinous bud scar remains on both the mother and daughter cell. [2][3]

References
  1. O'Connor C (2008). "Cell Division: Stages of Mitosis". Nature Education. 1 (1): 188.
  2. Cabib E, Roh DH, Schmidt M, Crotti LB, Varma A (June 2001). "The yeast cell wall and septum as paradigms of cell growth and morphogenesis". The Journal of Biological Chemistry. 276 (23): 19679–82. doi:10.1074/jbc.R000031200. PMID 11309404.
  3. Lesage G, Bussey H (June 2006). "Cell wall assembly in Saccharomyces cerevisiae". Microbiology and Molecular Biology Reviews. 70 (2): 317–43. doi:10.1128/MMBR.00038-05. PMC 1489534. PMID 16760306.
  4. García Cortés JC, Ramos M, Osumi M, Pérez P, Ribas JC (September 2016). "The Cell Biology of Fission Yeast Septation". Microbiology and Molecular Biology Reviews. 80 (3): 779–91. doi:10.1128/MMBR.00013-16. PMC 4981666. PMID 27466282.
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