SUV39H2

SUV39H2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R3A
Identifiers
Aliases	SUV39H2, KMT1B, suppressor of variegation 3-9 homolog 2
External IDs	OMIM: 606503 MGI: 1890396 HomoloGene: 32548 GeneCards: SUV39H2
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	14,904,315 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	3,475,031 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• methyltransferase activity; • transferase activity; • histone methyltransferase activity (H3-K9 specific); • transcription regulatory region sequence-specific DNA binding; • metal ion binding; • GO:0001948 protein binding; • histone-lysine N-methyltransferase activity; • zinc ion binding; • S-adenosyl-L-methionine binding;
Cellular component	• chromosome; • nucleoplasm; • chromatin; • chromosome, centromeric region; • cell nucleus;
Biological process	• chromatin remodeling; • cell differentiation; • regulation of transcription, DNA-templated; • rhythmic process; • histone H3-K9 dimethylation; • negative regulation of circadian rhythm; • negative regulation of transcription from RNA polymerase II promoter; • chromatin assembly or disassembly; • transcription, DNA-templated; • histone H3-K9 trimethylation; • methylation; • histone lysine methylation; • cell cycle; • negative regulation of transcription, DNA-templated; • cellular response to hypoxia; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	79723
	64707
	ENSG00000152455
	ENSMUSG00000026646
	Q9H5I1
	Q9EQQ0
	NM_001193424; NM_001193425; NM_001193426; NM_001193427; NM_024670
	NM_022724
	NP_001180353; NP_001180354; NP_001180355; NP_001180356; NP_078946
	NP_073561
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000152455 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026646 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol. 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.
"Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–9. doi:10.1038/35020506. PMID 10949293.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells". EMBO J. 23 (3): 605–15. doi:10.1038/sj.emboj.7600074. PMC 1271807. PMID 14765126.
Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression". Oncogene. 23 (30): 5242–51. doi:10.1038/sj.onc.1207660. PMID 15107829.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer". Carcinogenesis. 27 (11): 2217–22. doi:10.1093/carcin/bgl084. PMID 16774942.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152455 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026646 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11094092-5] O'Carroll D, Scherthan H, Peters AH, Opravil S, Haynes AR, Laible G, Rea S, Schmid M, Lebersorger A, Jerratsch M, Sattler L, Mattei MG, Denny P, Brown SD, Schweizer D, Jenuwein T (Dec 2000). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression". Mol Cell Biol. 20 (24): 9423–33. doi:10.1128/MCB.20.24.9423-9433.2000. PMC 102198. PMID 11094092.

[entrez-6] "Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)".

SUV39H2

References

Further reading