STS-1 (gene)

UBASH3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CPW, 2E5K
Identifiers
Aliases	UBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
External IDs	OMIM: 609201 MGI: 1920078 HomoloGene: 13152 GeneCards: UBASH3B
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	122,814,473 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	41,161,697 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• protein tyrosine phosphatase activity; • GO:0001948 protein binding; • phosphoprotein phosphatase activity; • hydrolase activity; • identical protein binding; • phosphoprotein binding; • ubiquitin protein ligase binding; • phosphatase activity;
Cellular component	• cytoplasm; • cell nucleus;
Biological process	• regulation of release of sequestered calcium ion into cytosol; • negative regulation of signal transduction; • peptidyl-tyrosine dephosphorylation; • negative regulation of platelet aggregation; • regulation of osteoclast differentiation; • negative regulation of protein kinase activity; • negative regulation of osteoclast differentiation; • negative regulation of bone resorption; • platelet activation; • collagen-activated tyrosine kinase receptor signaling pathway; • collagen-activated signaling pathway; • platelet aggregation; • regulation of protein binding;
	Sources:Amigo / QuickGO
Orthologs
	84959
	72828
	ENSG00000154127
	ENSMUSG00000032020
	Q8TF42
	Q8BGG7
	NM_032873; NM_001363365
	NM_176860; NM_001357412
	NP_116262; NP_001350294
	NP_789830; NP_001344341
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.[5][6][7]

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.[7]

References

GRCh38: Ensembl release 89: ENSG00000154127 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032020 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669. PMID 12370296.
"Entrez Gene: STS-1 Cbl-interacting protein Sts-1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
Guo F, Sigua C, Bali P, et al. (2005). "Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells". Blood. 105 (3): 1246–55. doi:10.1182/blood-2004-05-2041. PMID 15388581.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154127 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032020 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11853319-5] Nagase T, Kikuno R, Ohara O (Feb 2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.

[pmid12370296-6] Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou ST, Feng J, Nakajima H, Ihle JN (Oct 2002). "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein". Mol Cell Biol. 22 (21): 7491–500. doi:10.1128/MCB.22.21.7491-7500.2002. PMC 135669. PMID 12370296.

[entrez-7] "Entrez Gene: STS-1 Cbl-interacting protein Sts-1".

STS-1 (gene)

References

Further reading