STEAP1

Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.[5]

STEAP1
Identifiers
Aliases	STEAP1, PRSS24, STEAP, six transmembrane epithelial antigen of the prostate 1, STEAP family member 1
External IDs	OMIM: 604415 MGI: 1917608 HomoloGene: 8256 GeneCards: STEAP1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.13 Start 90,154,456 bp[1] End 90,164,829 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A1|5 3.2 cM Start 5,736,317 bp[2] End 5,749,326 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ferric-chelate reductase (NADPH) activity • metal ion binding • transporter activity • oxidoreductase activity • cupric reductase activity • channel activity Cellular component • endosome membrane • integral component of membrane • intercellular junction • integral component of plasma membrane • membrane • endosome • cell membrane Biological process • oxidation-reduction process • ion transport • copper ion import • iron ion homeostasis • transmembrane transport • ferric iron import across plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26872	70358
Ensembl	ENSG00000164647	ENSMUSG00000015652
UniProt	Q9UHE8	Q9CWR7
RefSeq (mRNA)	NM_012449	NM_027399
RefSeq (protein)	NP_036581	NP_081675
Location (UCSC)	Chr 7: 90.15 – 90.16 Mb	Chr 5: 5.74 – 5.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.[5]