STC2

STC2
Identifiers
Aliases	STC2, STC-2, STCRP, stanniocalcin 2
External IDs	OMIM: 603665 MGI: 1316731 HomoloGene: 2753 GeneCards: STC2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	173,329,503 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	31,370,074 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • hormone activity; • heme binding; • enzyme binding;
Cellular component	• Golgi apparatus; • extracellular region; • endoplasmic reticulum; • perinuclear region of cytoplasm; • extracellular; • endoplasmic reticulum lumen;
Biological process	• response to vitamin D; • calcium ion homeostasis; • negative regulation of multicellular organism growth; • response to peptide hormone; • cellular calcium ion homeostasis; • regulation of hormone biosynthetic process; • response to oxidative stress; • negative regulation of gene expression; • response to endoplasmic reticulum stress; • endoplasmic reticulum unfolded protein response; • decidualization; • regulation of store-operated calcium entry; • cellular response to hypoxia; • embryo implantation; • post-translational modification; • cellular protein metabolic process; • regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	8614
	20856
	ENSG00000113739
	ENSMUSG00000020303
	O76061
	O88452
	NM_003714
	NM_011491
	NP_003705
	NP_035621
	Wikidata
View/Edit Human	View/Edit Mouse

Stanniocalcin-2 is a protein that in humans is encoded by the STC2 gene.[5][6][7]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues.

Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.[7]

References

GRCh38: Ensembl release 89: ENSG00000113739 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020303 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol. 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890.
Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun. 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616.
"Entrez Gene: STC2 stanniocalcin 2".

DiMattia GE, Varghese R, Wagner GF (1999). "Molecular cloning and characterization of stanniocalcin-related protein". Mol. Cell. Endocrinol. 146 (1–2): 137–40. doi:10.1016/S0303-7207(98)00163-4. PMID 10022771.
Moore EE, Kuestner RE, Conklin DC, et al. (1999). "Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells". Horm. Metab. Res. 31 (7): 406–14. doi:10.1055/s-2007-978764. PMID 10450831.
Jellinek DA, Chang AC, Larsen MR, et al. (2001). "Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells". Biochem. J. 350 Pt 2 (2): 453–61. doi:10.1042/0264-6021:3500453. PMC 1221272. PMID 10947959.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gagliardi AD, Kuo EY, Raulic S, et al. (2005). "Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs". Am. J. Physiol. Endocrinol. Metab. 288 (1): E92–105. doi:10.1152/ajpendo.00268.2004. PMID 15367391.
Luo CW, Pisarska MD, Hsueh AJ (2005). "Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary". Endocrinology. 146 (1): 469–76. doi:10.1210/en.2004-1197. PMID 15486227.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Esseghir S, Kennedy A, Seedhar P, et al. (2007). "Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins". Clin. Cancer Res. 13 (11): 3164–73. doi:10.1158/1078-0432.CCR-07-0224. PMID 17545519.
Ichikawa T, Horie-Inoue K, Ikeda K, et al. (2007). "Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells". J. Mol. Endocrinol. 39 (4): 239–47. doi:10.1677/JME-07-0048. PMID 17909264.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113739 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020303 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9723890-5] Chang AC, Reddel RR (Nov 1998). "Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2". Mol Cell Endocrinol. 141 (1–2): 95–9. doi:10.1016/S0303-7207(98)00097-5. PMID 9723890.

[pmid9753616-6] Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai M (Nov 1998). "Molecular cloning of a second human stanniocalcin homologue (STC2)". Biochem Biophys Res Commun. 250 (2): 252–8. doi:10.1006/bbrc.1998.9300. PMID 9753616.

[entrez-7] "Entrez Gene: STC2 stanniocalcin 2".

STC2

References

Further reading