SPC24

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.[5]

SPC24
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSPC24, SPBC24, NDC80 kinetochore complex component, SPC24 component of NDC80 kinetochore complex
External IDsOMIM: 609394 MGI: 1914879 HomoloGene: 12166 GeneCards: SPC24
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.2Start11,131,520 bp[1]
End11,155,808 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

147841

67629

Ensembl

ENSG00000161888

ENSMUSG00000074476

UniProt

Q8NBT2

Q9D083

RefSeq (mRNA)

NM_182513
NM_001317031
NM_001317032
NM_001317033

NM_026282
NM_001357331

RefSeq (protein)

NP_001303960
NP_001303961
NP_001303962
NP_872319

NP_080558
NP_001344260

Location (UCSC)Chr 19: 11.13 – 11.16 MbChr 9: 21.76 – 21.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000161888 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000074476 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272.
  • Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (August 2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". The Journal of Biological Chemistry. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
  • Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  • McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT (January 2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Current Biology. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735.
  • Bharadwaj R, Qi W, Yu H (March 2004). "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.
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