SLU7

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.[5][6][7]

SLU7
Identifiers
AliasesSLU7, 9G8, hSlu7, SLU7 homolog, splicing factor
External IDsOMIM: 605974 MGI: 2385598 HomoloGene: 4690 GeneCards: SLU7
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.3Start160,401,641 bp[1]
End160,421,711 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10569

193116

Ensembl

ENSG00000164609

ENSMUSG00000020409

UniProt

O95391

Q8BHJ9

RefSeq (mRNA)

NM_006425

NM_148673
NM_198936

RefSeq (protein)

NP_683514
NP_945174

Location (UCSC)Chr 5: 160.4 – 160.42 MbChr 11: 43.43 – 43.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
  6. Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
  7. "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

Further reading


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