SH3GLB2

Endophilin-B2 is a protein that in humans is encoded by the SH3GLB2 gene.[5][6]

SH3GLB2
Identifiers
AliasesSH3GLB2, PP6569, PP9455, RRIG1, SH3 domain containing GRB2 like endophilin B2, SH3 domain containing GRB2 like, endophilin B2
External IDsOMIM: 609288 MGI: 2385131 HomoloGene: 10595 GeneCards: SH3GLB2
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.11Start129,007,036 bp[1]
End129,028,303 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56904

227700

Ensembl

ENSG00000148341

ENSMUSG00000026860

UniProt

Q9NR46

Q8R3V5

RefSeq (mRNA)

NM_001289709
NM_001289710
NM_139302
NM_001346806
NM_001362888

RefSeq (protein)

NP_001276638
NP_001276639
NP_001333735
NP_647463
NP_001349817

Location (UCSC)Chr 9: 129.01 – 129.03 MbChr 2: 30.34 – 30.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

SH3GLB2 has been shown to interact with SH3GLB1[5] and SH3KBP1.[7][8]

References
  1. GRCh38: Ensembl release 89: ENSG00000148341 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026860 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
  6. "Entrez Gene: SH3GLB2 SH3-domain GRB2-like endophilin B2".
  7. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
  8. Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.

Further reading
  • Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  • Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Mikula M, Dzwonek A, Karczmarski J, Rubel T, Dadlez M, Wyrwicz LS, Bomsztyk K, Ostrowski J (2006). "Landscape of the hnRNP K protein-protein interactome". Proteomics. 6 (8): 2395–406. doi:10.1002/pmic.200500632. PMID 16518874.


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