SH3GL3

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.[5][6]

SH3GL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSH3GL3, CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13, SH3 domain containing GRB2 like endophilin A3, SH3 domain containing GRB2 like 3, endophilin A3
External IDsOMIM: 603362 MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q25.2Start83,447,228 bp[1]
End83,618,743 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6457

20408

Ensembl

ENSG00000140600

ENSMUSG00000030638

UniProt

Q99963

Q62421

RefSeq (mRNA)

NM_001277954
NM_001277955
NM_017400

RefSeq (protein)

NP_001264883
NP_001264884
NP_059096

Location (UCSC)Chr 15: 83.45 – 83.62 MbChr 7: 82.17 – 82.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

SH3GL3 has been shown to interact with Huntingtin[7] and SH3KBP1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000140600 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030638 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
  6. "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".
  7. Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.
  8. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

Further reading


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