SGSM2

SGSM2
Identifiers
Aliases	SGSM2, RUTBC1, small G protein signaling modulator 2
External IDs	OMIM: 611418 MGI: 2144695 HomoloGene: 14780 GeneCards: SGSM2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	2,381,058 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	74,897,060 bp[2]
Gene ontology
Molecular function	• Rab GTPase binding; • GTPase activator activity;
Cellular component	• endomembrane system; • cytoplasm; • melanosome;
Biological process	• late endosome to Golgi transport; • positive regulation of GTPase activity; • activation of GTPase activity; • regulation of vesicle fusion; • intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	9905
	97761
	ENSG00000141258
	ENSMUSG00000038351
	O43147
	Q80U12
	NM_001098509; NM_014853; NM_001346700
	NM_197943; NM_001374688
	NP_001091979; NP_001333629; NP_055668
	NP_922934; NP_001361617
	Wikidata
View/Edit Human	View/Edit Mouse

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.[5][6]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.[7]

GRCh38: Ensembl release 89: ENSG00000141258 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038351 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yang, H; et al. (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
"Entrez Gene: small G protein signaling modulator 2".
Strawbridge, RJ; et al. (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Vasan RS, Glazer NL, Felix JF, et al. (2009). "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data". JAMA. 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346.
Ishikawa K, Nagase T, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Yang H; Sasaki T; Minoshima S; Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
Ishibashi K; Kanno E; Itoh T; Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.

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