SF3A3

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.[5][6][7]

SF3A3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSF3A3, PRP9, PRPF9, SAP61, SF3a60, splicing factor 3a subunit 3
External IDsOMIM: 605596 MGI: 1922312 HomoloGene: 4949 GeneCards: SF3A3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p34.3Start37,956,975 bp[1]
End37,990,075 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10946

75062

Ensembl

ENSG00000183431

ENSMUSG00000028902

UniProt

Q12874

Q9D554

RefSeq (mRNA)

NM_006802
NM_001320830

NM_029157

RefSeq (protein)

NP_001307759
NP_006793

NP_083433

Location (UCSC)Chr 1: 37.96 – 37.99 MbChr 4: 124.71 – 124.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.[7]

Interactions

SF3A3 has been shown to interact with SF3A1.[6][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000183431 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028902 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kramer A; Legrain P; Mulhauser F; Groning K; Brosi R; Bilbe G (February 1995). "Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo". Nucleic Acids Res. 22 (24): 5223–8. doi:10.1093/nar/22.24.5223. PMC 332064. PMID 7816610.
  6. Chiara MD; Champion-Arnaud P; Buvoli M; Nadal-Ginard B; Reed R (August 1994). "Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114". Proc Natl Acad Sci U S A. 91 (14): 6403–7. Bibcode:1994PNAS...91.6403C. doi:10.1073/pnas.91.14.6403. PMC 44210. PMID 8022796.
  7. "Entrez Gene: SF3A3 splicing factor 3a, subunit 3, 60kDa".
  8. Nesic, D; Krämer A (October 2001). "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation". Mol. Cell. Biol. United States. 21 (19): 6406–17. doi:10.1128/MCB.21.19.6406-6417.2001. ISSN 0270-7306. PMC 99788. PMID 11533230.

Further reading

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