SEC23IP

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.[5][6]

SEC23IP
Identifiers
AliasesSEC23IP, P125, P125A, MSTP053, SEC23 interacting protein
External IDsOMIM: 617852 MGI: 2450915 HomoloGene: 38288 GeneCards: SEC23IP
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q26.11-q26.12Start119,892,730 bp[1]
End119,944,657 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11196

207352

Ensembl

ENSG00000107651

ENSMUSG00000055319

UniProt

Q9Y6Y8

Q6NZC7

RefSeq (mRNA)

NM_007190

NM_001029982

RefSeq (protein)

NP_009121

n/a

Location (UCSC)Chr 10: 119.89 – 119.94 MbChr 7: 128.74 – 128.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000107651 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055319 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
  6. "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading


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