Roundup (herbicide)

Roundup is the brand name of a systemic, broad-spectrum glyphosate-based herbicide originally produced by Monsanto, which Bayer acquired in 2018.[2] Glyphosate is the most widely used herbicide in the United States.[3] As of 2009, sales of Roundup herbicides still represented about 10 percent of Monsanto's revenue despite competition from Chinese producers of other glyphosate-based herbicides.[4] The overall Roundup line of products, which includes genetically modified seeds, represented about half of Monsanto's yearly revenue.[5] The product is marketed to consumers by Scotts Miracle-Gro Company.[6]

This article is about the herbicide developed by Monsanto. For the active ingredient alone, see glyphosate.
Roundup
Manufacturing status
ManufacturerBayer
TypeHerbicide
Introduced to market1976[1]
Purposes
AgricultureNon-selective post-emergence weed control
Herbicide properties
SurfactantPolyethoxylated tallow amine (most common)
Main active ingredientIsopropylamine salt of glyphosate
Mode of action5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitor

Monsanto developed and patented the glyphosate molecule in the 1970s, and marketed it as Roundup from 1973. It retained exclusive rights to glyphosate in the US until its US patent expired in September 2000; in other countries the patent expired earlier. The Roundup trademark is registered with the US Patent Office and still extant. However, glyphosate is no longer under patent, so similar products use it as an active ingredient.[7]

The main active ingredient of Roundup is the isopropylamine salt of glyphosate. Another ingredient of Roundup is the surfactant POEA (polyethoxylated tallow amine).

Monsanto also produced seeds which grow into plants genetically engineered to be tolerant to glyphosate, which are known as Roundup Ready crops. The genes contained in these seeds are patented. Such crops allow farmers to use glyphosate as a post-emergence herbicide against most broadleaf and cereal weeds.

Composition

Beyond the glyphosate salt content, commercial formulations of Roundup contain surfactants, which vary in nature and concentration. As a result, the primary and secondary effects of this herbicide are not exclusively due to the main active ingredient.[8]

Acute toxicity
Further information: The dose makes the poison

The lethal dose of different glyphosate-based formulations varies, especially with respect to the surfactants used. Formulations intended for terrestrial use that include the surfactant polyethoxylated tallow amine (POEA) can be more toxic than other formulations for aquatic species.[9][10] Due to the variety in available formulations, including five different glyphosate salts and different combinations of inert ingredients, it is difficult to determine how much surfactants contribute to the overall toxicity of each formulation.[11][12] Independent scientific reviews and regulatory agencies have regularly concluded that glyphosate-based herbicides do not lead to a significant risk for human or environmental health when the product label is properly followed.[13]

Human

The acute oral toxicity for mammals is low,[9] but death has been reported after deliberate overdose of concentrated Roundup.[14] The surfactants in glyphosate formulations can increase the relative acute toxicity of the formulation.[12] Surfactants generally do not, however, cause synergistic effects (as opposed to additive effects) that increase the acute toxicity of glyphosate within a formulation.[12] The surfactant POEA is not considered an acute toxicity hazard, and has an oral toxicity similar to vitamin A and less toxic than aspirin.[15] Deliberate ingestion of Roundup ranging from 85 to 200 ml (of 41% solution) has resulted in death within hours of ingestion, although it has also been ingested in quantities as large as 500 ml with only mild or moderate symptoms.[16] Consumption of over 85 ml of concentrated product is likely to cause serious symptoms in adults, including burns due to corrosive effects as well as kidney and liver damage. More severe cases lead to "respiratory distress, impaired consciousness, pulmonary edema, infiltration on chest X-ray, shock, arrhythmias, kidney failure requiring haemodialysis, metabolic acidosis, and hyperkalaemia" and death is often preceded by bradycardia and ventricular arrhythmias.[12]

Skin exposure can cause irritation, and photocontact dermatitis has been occasionally reported. Severe skin burns are very rare.[12] In a 2017 risk assessment, the European Chemicals Agency (ECHA) wrote: "There is very limited information on skin irritation in humans. Where skin irritation has been reported, it is unclear whether it is related to glyphosate or co-formulants in glyphosate-containing herbicide formulations." The ECHA concluded that available human data was insufficient to support classification for skin corrosion or irritation.[17]

Inhalation is a minor route of exposure, but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, or tingling and irritation in the throat. Eye exposure may lead to mild conjunctivitis. Superficial corneal injury is possible if irrigation is delayed or inadequate.[12]

Aquatic

Glyphosate formulations with POEA, such as Roundup, are not approved for aquatic use due to aquatic organism toxicity.[18] Due to the presence of POEA, glyphosate formulations only allowed for terrestrial use are more toxic for amphibians and fish than glyphosate alone.[18][19][20] Terrestrial glyphosate formulations that include the surfactants POEA and MON 0818 (75% POEA) may have negative impacts on various aquatic organisms like protozoa, mussels, crustaceans, frogs and fish.[9] Aquatic organism exposure risk to terrestrial formulations with POEA is limited to drift or temporary water pockets.[18] While laboratory studies can show effects of glyphosate formulations on aquatic organisms, similar observations rarely occur in the field when instructions on the herbicide label are followed.[13]

Studies in a variety of amphibians have shown the toxicity of products containing POEA to amphibian larvae. These effects include interference with gill morphology and mortality from either the loss of osmotic stability or asphyxiation. At sub-lethal concentrations, exposure to POEA or glyphosate/POEA formulations have been associated with delayed development, accelerated development, reduced size at metamorphosis, developmental malformations of the tail, mouth, eye and head, histological indications of intersex and symptoms of oxidative stress.[20] Glyphosate-based formulations can cause oxidative stress in bullfrog tadpoles.[21] The use of glyphosate-based pesticides are not considered the major cause of amphibian decline, the bulk of which occurred prior to widespread use of glyphosate or in pristine tropical areas with minimal glyphosate exposure.[22]

A 2000 review of the toxicological data on Roundup concluded that "for terrestrial uses of Roundup minimal acute and chronic risk was predicted for potentially exposed nontarget organisms". It also concluded that there were some risks to aquatic organisms exposed to Roundup in shallow water.[23]

Carcinogenicity

There is limited evidence that human cancer risk might increase as a result of occupational exposure to large amounts of glyphosate, such as agricultural work, but no good evidence of such a risk from home use, such as in domestic gardening.[24] The consensus among national pesticide regulatory agencies and scientific organizations is that labeled uses of glyphosate have demonstrated no evidence of human carcinogenicity.[25] Organizations such as the Joint FAO/WHO Meeting on Pesticide Residues and the European Commission, Canadian Pest Management Regulatory Agency, and the German Federal Institute for Risk Assessment[26] have concluded that there is no evidence that glyphosate poses a carcinogenic or genotoxic risk to humans. The final assessment of the Australian Pesticides and Veterinary Medicines Authority in 2017 was that "glyphosate does not pose a carcinogenic risk to humans".[27] The EPA has evaluated the carcinogenic potential of glyphosate multiple times since 1986. In 1986, glyphosate was initially classified as Group C: "Possible Human Carcinogen", but later recommended as Group D: "Not Classifiable as to Human Carcinogenicity" due to lack of statistical significance in previously examined rat tumor studies. In 1991, it was classified as Group E: "Evidence of Non-Carcinogenicity for Humans", and in 2015 and 2017, "Not Likely to be Carcinogenic to Humans".[28][29]

One international scientific organization, the International Agency for Research on Cancer, classified glyphosate in Group 2A, "probably carcinogenic to humans" in 2015.[21] The variation in classification between this agency and others has been attributed to "use of different data sets" and "methodological differences in the evaluation of the available evidence".[25] In 2017, California environmental regulators listed glyphosate as “known to the state to cause cancer.” The state's Office of Environmental Health Hazard Assessment made the decision based in part on the report from the International Agency for Research on Cancer. State Proposition 65 requires the state office to add all substances the international agency deems carcinogenic to a state list of cancer-causing items.

In a 2003 internal email, a Monsanto toxicologist wrote, "you cannot say that Roundup is not a carcinogen... we have not done the necessary testing on the formulation to make that statement. The testing on the formulations are not anywhere near the level of the active ingredient. We can make that statement about glyphosate and can infer that there is no reason to believe that Roundup would cause cancer." In a 2002 email also obtained as part of discovery in the court case, a Monsanto scientist wrote to a colleague, "we are in pretty good shape with glyphosate but vulnerable with surfactants. What I've been hearing from you is that this continues to be the case with these studies – Glyphosate is OK but the formulated product (and thus the surfactant) does the damage."[30][31]

In the ten months following Bayer's June 2018 acquisition of Monsanto, its stock lost 46% of its value because of investor apprehension concerning the 11,200 lawsuits filed against its subsidiary.[32]

Cancer cases

As of October 30, 2019, there were over 42,000 plaintiffs who said that glyphosate herbicides caused their cancer.[33] After the IARC classified glyphosate as "probably carcinogenic to humans"[21] in 2015, many state and federal lawsuits were filed in the United States. Early on, over 300 of them were consolidated into a multidistrict litigation called In re: RoundUp Products Liability.[34]

On 10 August 2018, Dewayne Johnson, who has non-Hodgkin's lymphoma, was awarded $289 million in damages (later cut to $78 million on appeal[35]) after a jury in San Francisco found that Monsanto had failed to adequately warn consumers of cancer risks posed by the herbicide.[36][37] Johnson had routinely used two different glyphosate formulations in his work as a groundskeeper, RoundUp and another Monsanto product called Ranger Pro.[38][39] The jury's verdict addressed the question of whether Monsanto knowingly failed to warn consumers that RoundUp could be harmful, but not whether RoundUp causes cancer.[40] Court documents from the case show the company's efforts to influence scientific research via ghostwriting.[41]

In January 2019, Costco decided to stop carrying Roundup or other glyphosate-based herbicides. The decision was reportedly influenced in part by the public court cases.[42]

In March 2019, a man was awarded $80 million (later cut to $26 million on appeal[43]) in a lawsuit claiming Roundup was a substantial factor in his cancer.[44][45] U.S. District Judge Vince Chhabria stated that a punitive award was appropriate because the evidence "easily supported a conclusion that Monsanto was more concerned with tamping down safety inquiries and manipulating public opinion than it was with ensuring its product is safe." Chhabria stated that there was evidence on both sides as to whether glyphosate causes cancer, and that the behavior of Monsanto showed "a lack of concern about the risk that its product might be carcinogenic."[43]

On 13 May 2019 a jury in California ordered Bayer to pay a couple $2 billion in damages (later cut to $87 million on appeal[46]) after finding that the company had failed to adequately inform consumers of the possible carcinogenicity of Roundup.[47] On 19 December 2019, it was announced that Timothy Litzenburg, the lawyer for the RoundUp Virginia plaintiffs had been charged with extortion after offering to stop searching for more plaintiffs if he was paid a $200m consulting fee by Bayer and Monsanto.[48][49][50]

In June 2020, Bayer agreed to settle over a hundred thousand Roundup lawsuits, agreeing to pay $8.8 to $9.6 billion to settle those claims, and $1.5 billion for any future claims. The settlement does not include three cases that have already gone to jury trials and are being appealed.[51]

False advertising

In 1996, Monsanto was accused of false and misleading advertising of glyphosate products, prompting a lawsuit by the New York State attorney general.[52] Monsanto had made claims that its spray-on glyphosate based herbicides, including Roundup, were safer than table salt and "practically non-toxic" to mammals, birds, and fish, "environmentally friendly", and "biodegradable".[53][54] Citing avoidance of costly litigation, Monsanto settled the case, admitting no wrongdoing, and agreeing to remove the offending advertising claims in New York State.[54]

Environmental and consumer rights campaigners brought a case in France in 2001 accusing Monsanto of presenting Roundup as "biodegradable" and claiming that it "left the soil clean" after use; glyphosate, Roundup's main ingredient, was classed by the European Union as "dangerous for the environment" and "toxic for aquatic organisms". In January 2007, Monsanto was convicted of false advertising and fined 15,000 euros. The result was confirmed in 2009.[55][56]

On 27 March 2020 Bayer settled claims in a proposed class action alleging that it falsely advertised that the active ingredient in Roundup Weed & Grass Killer only affects plants with a $39.5 million deal that included changing the labels on its products.[57]

Falsification of test results

Some tests originally conducted on glyphosate by contractors were later found to have been fraudulent, along with tests conducted on other pesticides. Concerns were raised about toxicology tests conducted by Industrial Bio-Test Laboratories in the 1970s[58] and Craven Laboratories was found to have fraudulently analysed samples for residues of glyphosate in 1991.[59] Monsanto has stated that the studies have since been repeated.[60]

Ban in France

In January 2019, Roundup 360 was banned in France following a Lyon court ruling that regulator ANSES had not given due weight to safety concerns when they approved the product in March 2017. The ban went into effect immediately. The court's decision cited research by the IARC, based in Lyon.[61][62]

Genetically modified crops
Main article: Roundup Ready

Roundup was first developed in the 1970s by Monsanto. It was initially used in a similar way to paraquat and diquat, as a non-selective herbicide. Attempts were made to apply glyphosate-based herbicides to row crops, but problems with crop damage kept them from being widely used for this purpose. In the United States, use of Roundup experienced rapid growth following the commercial introduction of a glyphosate-resistant soybean in 1996.[63] "Roundup Ready" became the company trademark for its patented line of crop seed that are resistant to Roundup. Between 1990 and 1996 sales of Roundup increased around 20% per year.[64] As of 2015 it is used in over 160 countries.[65] Roundup is used most heavily on corn, soy, and cotton crops that have been genetically modified to withstand the chemical, but since 2012 glyphosate was used in California to treat other crops like almond, peach, cantaloupe, onion, cherry, sweet corn, and citrus.[65]

See also

References
  1. "Monsanto ~ Who We Are ~ Company History". Monsanto.com. 2008-11-03. Archived from the original on April 23, 2008. Retrieved 2010-08-22.
  2. "Monsanto No More: Agri-Chemical Giant's Name Dropped In Bayer Acquisition". NPR.org. Retrieved 2018-08-17.
  3. US EPA 2000–2001 Pesticide Market Estimates Agriculture, Home and Garden
  4. "The debate over whether Monsanto is a corporate sinner or saint". The Economist. 19 November 2009. Retrieved 20 November 2009.
  5. Cavallaro, Matt (2009-06-26). "The Seeds Of A Monsanto Short Play". Forbes. Retrieved 2009-07-11.
  6. Jack Kaskey (2019-05-01). "Scotts Miracle-Gro Jumps Most in Decade on Pot-Supplies Rebound". Bloomberg.
  7. "California Product/Label Database". Cdpr.ca.gov. Retrieved 2010-08-22.
  8. Review article at of glyphosate poisoning at Pubmed by Bradberry SM, Proudfoot AT, Vale JA. of the National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham, UK. National Institutes of Health
  9. Van Bruggen, A.H.C.; He, M.M.; Shin, K.; Mai, V.; Jeong, K.C.; Finckh, M. R.; Morris, J.G. (2018-03-01). "Environmental and health effects of the herbicide glyphosate". Science of the Total Environment. 616-617: 255–268. doi:10.1016/j.scitotenv.2017.10.309. ISSN 0048-9697. PMID 29117584.
  10. Effects of Surfactants on the Toxicity of Glyphosate, with Specific Reference to Rodeo (PDF), Syracuse Environmental Research Associates, Inc. (SERA), retrieved 2018-08-20
  11. Glyphosate: Human Health and Ecological Risk Assessment (PDF), Syracuse Environmental Research Associates, Inc.(SERA), retrieved 2018-08-20
  12. Bradberry SM, Proudfoot AT, Vale JA (2004). "Glyphosate poisoning". Toxicological Reviews. 23 (3): 159–67. doi:10.2165/00139709-200423030-00003. PMID 15862083.
  13. Rolando, Carol; Baillie, Brenda; Thompson, Dean; Little, Keith (12 June 2017). "The Risks Associated with Glyphosate-Based Herbicide Use in Planted Forests". Forests. 8 (6): 208. doi:10.3390/f8060208.
  14. Sribanditmongkol P, Jutavijittum P, Pongraveevongsa P, Wunnapuk K, Durongkadech P (Sep 2012). "Pathological and toxicological findings in glyphosate-surfactant herbicide fatality: a case report". The American Journal of Forensic Medicine and Pathology. 33 (3): 234–7. doi:10.1097/PAF.0b013e31824b936c. PMID 22835958.
  15. Williams, Gary M.; Kroes, Robert; Munro, Ian C. (April 2000). "Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans". Regulatory Toxicology and Pharmacology. 31 (2): 117–165. doi:10.1006/rtph.1999.1371. PMID 10854122.
  16. Talbot AR, Shiaw MH, Huang JS, Yang SF, Goo TS, Wang SH, Chen CL, Sanford TR (Jan 1991). "Acute poisoning with a glyphosate-surfactant herbicide ('Roundup'): a review of 93 cases". Human & Experimental Toxicology. 10 (1): 1–8. doi:10.1177/096032719101000101. PMID 1673618.
  17. Committee of Risk Assessment Opinion proposing harmonised classification and labelling at EU level of glyphosate (ISO); N-(phosphonomethyl)glycine
  18. "SS-AGR-104 Safe Use of Glyphosate-Containing Products in Aquatic and Upland Natural Areas" (PDF). University of Florida. Retrieved 13 August 2018.
  19. Gary L. Diamond and Patrick R. Durkin February 6, 1997, under contract from the United States Department of Agriculture. Effects of Surfactants on the Toxicity of Glyphosate, with Specific Reference to RODEO
  20. Mann RM, Hyne RV, Choung CB, Wilson SP (2009). "Amphibians and agricultural chemicals: Review of the risks in a complex environment". Environmental Pollution. 157 (11): 2903–2927. doi:10.1016/j.envpol.2009.05.015. PMID 19500891.
  21. "Glyphosate" (PDF). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. International Agency for Research on Cancer. 112. 11 August 2016. Retrieved July 31, 2019.
  22. Wagner N, Reichenbecher W, Teichmann H, Tappeser B, Lötters S (Aug 2013). "Questions concerning the potential impact of glyphosate-based herbicides on amphibians". Environmental Toxicology and Chemistry / SETAC. 32 (8): 1688–700. doi:10.1002/etc.2268. PMID 23637092.
  23. JP Giesy, KR Solomon, S Dobson (2000). "Ecotoxicological Risk Assessment for Roundup Herbicide". Reviews of Environmental Contamination and Toxicology 167: 35-120
  24. "Food Controversies—Pesticides and organic foods". Cancer Research UK. 2016. Retrieved 28 November 2017.
  25. Tarazona, Jose V.; Court-Marques, Daniele; Tiramani, Manuela; Reich, Hermine; Pfeil, Rudolf; Istace, Frederique; Crivellente, Federica (3 April 2017). "Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC". Archives of Toxicology. 91 (8): 2723–2743. doi:10.1007/s00204-017-1962-5. PMC 5515989. PMID 28374158.
  26. "The BfR has finalised its draft report for the re-evaluation of glyphosate - BfR". Retrieved 2018-08-18.
  27. Guston, David; Ludlow, Karinne (2010). "Australian Pesticides and Veterinary Medicines Authority". Encyclopedia of Nanoscience and Society. Thousand Oaks, Calif.: SAGE Publications. ISBN 978-1-4129-6987-1.
  28. US EPA, OCSPP (2017-12-18). "EPA Releases Draft Risk Assessments for Glyphosate" (Announcements and Schedules). US EPA. Retrieved 2018-08-18.
  29. "Revised Glyphosate Issue Paper: Evaluation of Carcinogenic Potential". EPA. pp. 12–13. Retrieved 24 September 2019.
  30. Gillam, Carey (2017-08-07). "Internal EPA Documents Show Scramble For Data On Monsanto's Roundup Herbicide". HuffPost. Retrieved 2019-11-04.
  31. Hakim, Danny (2017-08-01). "Monsanto Emails Raise Issue of Influencing Research on Roundup Weed Killer". The New York Times. ISSN 0362-4331. Retrieved 2019-11-05.
  32. Anaïs Moutot (28 March 2019). "Glyphosate: nouveau revers judiciare pour Bayer". Les Echos (in French). Retrieved 30 March 2019.
  33. "Bayer's Roundup Headache Grows as Plaintiffs Pile Into Court". Bloomberg. October 30, 2019. Retrieved 31 October 2019.
  34. "Monsanto's Cancer Fight Judge Pictures Weed Killer Showers". Bloomberg News. 2018-03-14. Retrieved 2018-08-17.
  35. Sullivan, Emily. "Groundskeeper Accepts Reduced $78 Million Award In Monsanto Cancer Suit". NPR. Retrieved 2019-07-29.
  36. "Monsanto ordered to pay $289 million in world's first Roundup..." Reuters. 2018-08-11. Retrieved 2018-08-17.
  37. "Weedkiller 'doesn't cause cancer' - Bayer". BBC News. 2018-08-11. Retrieved 2018-08-11.
  38. Johnston, Gretel (2018-08-11). "Dying cancer patient awarded $395m in Monsanto Roundup case". The Sydney Morning Herald. Retrieved 2018-08-18.
  39. Fee, Dawn M; Company, Monsato; Street, I. "United States Environmental Protection Agency Washington, D.C. 20460": 33. Cite journal requires |journal= (help)
  40. Ebersole, Rene (2018-08-17). "Monsanto Just Lost a Case Linking Its Weed Killer to Cancer". The Nation. ISSN 0027-8378. Retrieved 2018-08-18.
  41. Hakim, Danny (2018-08-01). "Monsanto Emails Raise Issue of Influencing Research on Roundup Weed Killer". The New York Times. Retrieved 2018-10-13.
  42. "Costco Will Reportedly Remove Roundup from Stores After $2 Billion Awarded to Couple Who Claimed Weed Killer Caused Their Cancer". PEOPLE.com. Retrieved 2019-12-08.
  43. "Judge Reduces $80M Award In Roundup Case; Cancer Patient, Monsanto Both Consider Appeal". San Francisco: KPIX-TV. Associated Press. 2019-07-15. Retrieved 2019-07-27.
  44. Gonzales, Richard (2019-03-29). "Jury Awards $80 Million In Damages In Roundup Weed Killer Cancer Trial". NPR. Retrieved 2019-07-29.
  45. Wolfson, Andrew (2019-03-28). "Louisville lawyer wins $80M verdict against Monsanto over weedkiller Roundup". The Courier-Journal. Louisville, Kentucky. Retrieved 2019-07-29.
  46. Telford, Taylor (2019-07-26). "Judge cuts $2 billion award for couple with cancer to $86.7 million in Roundup lawsuit". The Washington Post. Retrieved 2019-07-27.
  47. "Bayer's $2 Billion Roundup Damages Boost Pressure to Settle". Bloomberg News. Retrieved 2019-05-14.
  48. https://www.cbsnews.com/news/timothy-litzenburg-former-monsanto-roundup-lawyer-charged-with-extortion/
  49. https://www.agri-pulse.com/articles/12976-lawyer-for-roundup-plaintiffs-charged-with-extortion
  50. https://www.reuters.com/article/us-otc-masstorts/doj-charges-roundup-plaintiffs-lawyer-in-200-million-alleged-extortion-scheme-idUSKBN1YM2L9
  51. Bayer To Pay More Than $10 Billion To Resolve Cancer Lawsuits Over Weedkiller Roundup
  52. mindfully.org. "Attorney General of the State of New York. Consumer Frauds and Protection Bureau. Environmental Protection Bureau. 1996. In the matter of Monsanto Company, respondent. Assurance of discontinuance pursuant to executive law § 63(15). New York, NY, Nov". Mindfully.org. Retrieved 2010-08-22.
  53. "Monsanto pulls Roundup advertising in New York", Wichita Eagle, Nov. 27, 1996.
  54. "Monsanto Agrees to Modify Roundup Ads in New York State". Associated Press. 25 November 1996. Retrieved 14 October 2018.
  55. "Monsanto guilty in 'false ad' row". BBC News. 2009-10-15. Retrieved 2009-10-16.
  56. "Monsanto définitivement condamné pour "publicité mensongère" à propos du Round Up" [Monsanto finally convicted for 'false advertising' about the Round Up]. Le Monde (in French). Paris. 2009-10-15.
  57. "Monsanto To Pay $39M In Roundup False Ad Class Settlement - Law360". www.law360.com. Retrieved 2020-03-30.
  58. "Summary of the IBT review program". U.S. EPA Office of pesticides and Toxic Substances. July 1983.
  59. Keith Schneider (1991-03-02). "U.S. Seeks to Learn if Tests On Pesticides Were Falsified". New York Times. Retrieved 20 September 2018.
  60. "Testing Fraud: IBT and Craven Labs" (PDF). Backgrounder. Monsanto. June 2005.
  61. "Weedkiller Roundup banned in France after court ruling". France 24. 2019-01-16. Retrieved 2019-01-16.
  62. "French court cancels Monsanto weedkiller permit on safety grounds". Reuters. 15 January 2019. Retrieved 16 January 2019.
  63. Duke, Stephen O. (2018). "The history and current status of glyphosate". Pest Management Science. 74 (5): 1027–1034. doi:10.1002/ps.4652. PMID 28643882. Retrieved 20 August 2018.
  64. "Top-selling herbicide not close to withering". Wall Street Journal. 1996-01-08. Archived from the original on 2018-08-13. Retrieved 2018-08-12.
  65. "What Do We Really Know About Roundup Weed Killer?". National Geographic News. 2015-04-23. Archived from the original on 2018-08-13. Retrieved 2018-08-13.

Further reading
  • Baccara, Mariagiovanna, et al. ”Monsanto's Roundup”, NYU Stern School of Business: August 2001, Revised July 14, 2003.
  • Pease W S et al. (1993) ”Preventing pesticide-related illness in California agriculture: Strategies and priorities”. Environmental Health Policy Program Report. Berkeley, CA: University of California. School of Public Health. California Policy Seminar.
  • Wang Y, Jaw C and Chen Y (1994) “Accumulation of 2,4-D and glyphosate in fish and water hyaacinth”. Water Air Soil Pollute. 74:397–403
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