Reza Dana

Reza Dana is the Claes H. Dohlman Professor of Ophthalmology, Senior Scientist and W. Clement Stone Clinical Research Scholar at Massachusetts Eye and Ear, Harvard Medical School, and Director of the Harvard-Vision Clinical Scientist Development Program.[1]

Reza Dana
Dr.Reza Dana in 2019
EducationSt. Paul's School
Johns Hopkins University (BA,MD, MPH)
Illinois Eye and Ear Infirmary (Residency)
Wills Eye Hospital
Massachusetts Eye and Ear
Harvard University (MSc)
Known forDry Eye Disease
Corneal Transplantation Research
Medical career
FieldMedical research,
Immunology
Ophthalmology
InstitutionsMassachusetts Eye and Ear
Massachusetts General Hospital
Brigham and Women's Hospital
Harvard Medical School
Harvard University

Dana is an internationally recognized expert in the field of corneal disorders and ocular inflammation. He is best known for his work on the molecular and cellular mechanisms of ocular inflammation with translational applications to autoimmunity, transplantation, dry eye disease, and angiogenesis.[2] He is a member of editorial boards of 10 journals, including as editor-in-chief of Cornea.[3][4]

Education and training

Dana attended the Tehran International School during his early years and graduated Summa Cum Laude from St. Paul’s School, New Hampshire.[5] He pursued his baccalaureate degree at Johns Hopkins University School of Arts and Sciences where he was invited to join the Phi Beta Kappa. Dr. Dana attended medical school at Johns Hopkins School of Medicine, and also obtained a Masters in Public Health from Johns Hopkins Bloomberg School of Public Health.[6] He received his Ophthalmology residency training at the Illinois Eye and Ear Infirmary, and clinical cornea and external diseases fellowship at Wills Eye Hospital in Philadelphia. He received advanced fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear and pursued laboratory research training in Ocular and Transplantation Immunology Laboratory at the Schepens Eye Research Institute, Harvard Medical School under the mentorship of the late J. Wayne Streilein.[6]

Research and Career

Dr.Dana joined as an Instructor in the Department of Ophthalmology at Harvard Medical School in 1995 and has been a faculty member here ever since. In 2006, he was named the Director of Cornea Service at Massachusetts Eye and Ear, and in 2007, he was appointed the Claes H. Dohlman Chair in Ophthalmology and Vice Chairman for Academic Programs. He is also an Honorary Professor of Ophthalmology at Shanghai Medical College, Fudan University.[7]

Dr.Dana's research focus is in the area of immuno-inflammatory disorders of the cornea and ocular surface. He has published over 370 peer-reviewed publications and over 150 reviews, edited several books and serves as the Senior Editor for Elsevier’s Encyclopedia of the Eye.[8][9] His work has been cited more than 25000 times and carries an h-index of 82.[10] His is widely recognized for (i) identifying, phenotyping and functionally characterizing resident bone marrow-derived antigen-presenting cells (APC) of the cornea[11], (ii) identifying novel mechanisms of corneal APC trafficking[12], (iii) defining novel functional interactions between lymphatic endothelia and APC[13] (iv) identifying selective topical cytokine and chemokine targeting to promote transplant survival by suppressing effector T cells[14][15][16][17], (v) defining novel mechanisms employed by the corneal epithelium to maintain angiogenic privilege including the VEGFR-3 sink[18] and PD-L1 mechanisms[19], (vi) developing strategies to promote corneal endothelial cell survival in transplantation, including gene therapy.[20][21]

Awards and Honors

Dr.Joan Miller introducing Dr.Dana at the Friedenwald Award reception at Association for Research in Vision and Ophthalmology Annual Meeting 2018 in Honolulu.
Dr.Dana receiving the Ellis Island Medal of Honor in 2019
1981 National Cum Laude Society
1984 Phi Beta Kappa (Junior Year), Johns Hopkins University
1981-85 Dean's List (every semester), Johns Hopkins University
1989 Henry Strong Dennison Award for Research, Johns Hopkins School of Medicine
1990 National Eye Institute/ARVO Travel Fellowship
1995 Heed Ophthalmic Foundation Fellowship (Ocular Immunology)[22]
1996 Knapp Fellow of the Society of Heed Fellows[23]
1996 Clinical Scientist Career Award (KO8) from NIH
1999 Research to Prevent Blindness William & Mary Greve Special Scholar[24]
2002 Achievement Award, American Academy of Ophthalmology
2002 Kronfeld Memorial Lecturer, Illinois Eye & Ear Infirmary
2002 Fry Memorial Lecturer, Wills Eye Hospital Biennial Cornea Conference[25]
2003 Cogan Award, Association for Research In Vision and Ophthalmology[6]
2003 Dohlman Lecturer, Boston Biennial Cornea Conference
2004 Alta Lecturer and visiting professorship, University of California San Francisco[26]
2004 Keynote Address, 28th All-Japan Cornea Conference, Yonago, Japan
2005 Research to Prevent Blindness Physician Scientist-Merit Award
2006 Service Recognition Award, American Academy of Ophthalmology
2007 Listed, “Best Doctors of America”
2007 Listed, “Best of Boston” Ophthalmologists, Boston Magazine
2007 Listed, “Best Ophthalmologists of America”
2008 Alcon Research Institute Award[27]
2009 Research to Prevent Blindness Lew R. Wasserman-Merit Award
2011 David Easty Lecturer, Bowman Club, Royal College of Surgeons, Edinburgh
2011 Joaquin Barraquer Lecture, Spanish Congress of Ophthalmology[28]
2011 LSU Chancellor’s Award in Neuroscience and Ophthalmology[29]
2012 Mentoring Award, European Young Investigator Network for Ocular Surface Inflammation
2013 Senior Scientific Investigator Award, Research to Prevent Blindness
2013 Gold Fellow, Association for Research in Vision and Ophthalmology[30]
2013 Keynote Speaker, Biennial Meeting of the European Society of Ophthalmology, Copenhagen, Denmark
2014 Thygeson Lecture, Ocular Microbiology and Immunology Group[31]
2014 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School[32]
2015 Kersley Lecture, British Ocular Surface Society, London, England [33]
2015 Keynote Address & Certificate of Honor,European Association for Vision and Eye Research, Nice, France
2016 Roger Meyer Lecture, University of Michigan Kellogg Eye Center[34]
2016 Elected, Academia Ophthalmologica Internationalis[35]
2016 Mooney Lecture, Irish College of Ophthalmologists, Republic of Ireland[36]
2016 Endre A. Balazs Prize, International Society for Eye Research[37]
2017 Plenary Address, 121st Meeting of Japanese Ophthalmological Society[38]
2017 Senior Achievement Award, American Academy of Ophthalmology[39]
2017 Streilein Lecture, 30th Biennial Cornea Conference[40]
2018 Friedenwald Award, Association for Research in Vision and Ophthalmology (ARVO)[41]
2018 Research to Prevent Blindness Stein Innovation Award[42]
2019 Ellis Island Medal of Honor[43]
2020 Power List 2020 - The Ophthalmologist[44]

Teaching and Mentoring

Dr.Dana is the Vice Chair of Academic Programs at the Department of Ophthalmology, Massachusetts Eye and Ear and a faculty for the Graduate Program in Immunology, Harvard Medical School.[2] He is the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award, the top mentoring award bestowed at Harvard Medical School.[32] He has mentored over 120 postdoctoral research fellows from 33 countries, 80 clinical fellows and residents, medical students, and graduate students enrolled in Harvard Medical School. He is the Director of the NIH-funded Harvard-Vision Clinical Scientist Development Program since 2004.[45]

References

  1. "Research Profile: Reza Dana, M.D., M.Sc., MPH | Mass. Eye and Ear". www.masseyeandear.org. Retrieved 2019-07-12.
  2. Research Profie: Reza Dana, MD, MSc, MPH
  3. Dana, Reza (2020). "Letter From the New Editor-in-Chief". Cornea. 39 (1): 1. doi:10.1097/ICO.0000000000002231. ISSN 1536-4798. PMID 31764283.
  4. "Reza Dana, MD, MSc, MPH, FARVO". eye.hms.harvard.edu. Retrieved 2019-07-12.
  5. Memarian, Jahandad (September 14, 2017). "Reza Dana: Success Begins Outside Your Comfort Zone". HuffPost. Retrieved November 12, 2018.
  6. Streilein, J. Wayne (2004-03-01). "Introducing Reza Dana, the 2003 Recipient of the Cogan Award". Investigative Ophthalmology & Visual Science. 45 (3): 721. doi:10.1167/iovs.03-0509. ISSN 1552-5783.
  7. "Dana CV" (PDF).
  8. Dana, Reza. "Pubmed Bibliography". National Library of Medicine.
  9. Dana, Reza (2010). Encyclopedia of the Eye. Elsevier. ISBN 978-0-12-374198-1.
  10. "Google Scholar".
  11. Hamrah, Pedram; Huq, Syed O.; Liu, Ying; Zhang, Qiang; Dana, M. Reza (2003). "Corneal immunity is mediated by heterogeneous population of antigen-presenting cells". Journal of Leukocyte Biology. 74 (2): 172–178. doi:10.1189/jlb.1102544. ISSN 0741-5400. PMID 12885933.
  12. Liu, Ying; Hamrah, Pedram; Zhang, Qiang; Taylor, Andrew W.; Dana, M. Reza (2002-01-21). "Draining Lymph Nodes of Corneal Transplant Hosts Exhibit Evidence for Donor Major Histocompatibility Complex (MHC) Class II–positive Dendritic Cells Derived from MHC Class II–negative Grafts". The Journal of Experimental Medicine. 195 (2): 259–268. doi:10.1084/jem.20010838. ISSN 0022-1007. PMC 2193609. PMID 11805152.
  13. Chen, Lu; Hamrah, Pedram; Cursiefen, Claus; Zhang, Qiang; Pytowski, Bronislaw; Streilein, J. Wayne; Dana, M. Reza (2004). "Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity". Nature Medicine. 10 (8): 813–815. doi:10.1038/nm1078. ISSN 1078-8956. PMID 15235599.
  14. Huq, Syed; Liu, Ying; Benichou, Gilles; Dana, M. Reza (2004-10-01). "Relevance of the Direct Pathway of Sensitization in Corneal Transplantation Is Dictated by the Graft Bed Microenvironment". The Journal of Immunology. 173 (7): 4464–4469. doi:10.4049/jimmunol.173.7.4464. ISSN 0022-1767. PMID 15383577.
  15. Hattori, Takaaki; Saban, Daniel R.; Emami‐naeini, Parisa; Chauhan, Sunil K.; Funaki, Toshinari; Ueno, Hiroki; Dana, Reza (2012). "Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation". Journal of Leukocyte Biology. 91 (4): 621–627. doi:10.1189/jlb.1011500. ISSN 1938-3673. PMC 3317274. PMID 22291211.
  16. Dohlman, Thomas; Omoto, Masahiro; Hua, Jing; Stevenson, William; Lee, Sang-Mok; Chauhan, Sunil; Dana, Reza (2015). "VEGF-trap Aflibercept Significantly Improves Long-term Graft Survival in High-risk Corneal Transplantation". Transplantation. 99 (4): 678–686. doi:10.1097/TP.0000000000000512. ISSN 0041-1337. PMID 25606789.
  17. Amouzegar, Afsaneh; Chauhan, Sunil K.; Dana, Reza (2016-05-15). "Alloimmunity and Tolerance in Corneal Transplantation". The Journal of Immunology. 196 (10): 3983–3991. doi:10.4049/jimmunol.1600251. ISSN 0022-1767. PMC 4874505. PMID 27183635.
  18. Cursiefen, Claus; Chen, Lu; Saint-Geniez, Magali; Hamrah, Pedram; Jin, Yiping; Rashid, Saadia; Pytowski, Bronislaw; Persaud, Kris; Wu, Yan; Streilein, J. Wayne; Dana, Reza (2006-07-25). "Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision". Proceedings of the National Academy of Sciences of the United States of America. 103 (30): 11405–11410. Bibcode:2006PNAS..10311405C. doi:10.1073/pnas.0506112103. ISSN 0027-8424. PMC 1544098. PMID 16849433.
  19. Shen, Linling; Jin, Yiping; Freeman, Gordon J.; Sharpe, Arlene H.; Dana, M. Reza (2007-09-15). "The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival". Journal of Immunology. 179 (6): 3672–3679. doi:10.4049/jimmunol.179.6.3672. ISSN 0022-1767. PMID 17785803.
  20. Fuchsluger, T. A.; Jurkunas, U.; Kazlauskas, A.; Dana, R. (2011). "Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage". Gene Therapy. 18 (8): 778–787. doi:10.1038/gt.2011.20. ISSN 1476-5462. PMC 3587653. PMID 21412281.
  21. Fuchsluger, Thomas A.; Jurkunas, Ula; Kazlauskas, Andrius; Dana, Reza (2011). "Corneal endothelial cells are protected from apoptosis by gene therapy". Human Gene Therapy. 22 (5): 549–558. doi:10.1089/hum.2010.079. ISSN 1557-7422. PMC 3081440. PMID 21158568.
  22. "Heed Fellows || The Heed Foundation". www.heed.org. Retrieved 2019-11-10.
  23. "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Retrieved 2019-11-10.
  24. "Reza Dana | Harvard Catalyst Profiles | Harvard Catalyst". connects.catalyst.harvard.edu. Retrieved 2019-11-10.
  25. "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Retrieved 2019-11-10.
  26. "Honors and Distinctions - Schepens Eye Research Institute of Mass. Eye and Ear". www.schepens.harvard.edu. Retrieved 2019-11-10.
  27. "Alcon Research Institute Past Grant Recipients | MyAlcon.com". www.myalcon.com. Retrieved 2019-11-10.
  28. "Ever Association". www.everassociation.org. Retrieved 2019-11-10.
  29. "LSUHSC School of Medicine". www.medschool.lsuhsc.edu. Retrieved 2019-11-10.
  30. "The Association for Research in Vision and Ophthalmology- 2013 ARVO Fellows". www.arvo.org. Retrieved 2019-11-10.
  31. "Ocular Microbiology and Immunology Group, Inc". Ocular Microbiology and Immunology Group, Inc. Retrieved 2019-11-10.
  32. "A. Clifford Barger Excellence in Mentoring Award Recipients". The Office for Diversity Inclusion and Community Partnership at Harvard Medical School. Retrieved 2019-11-10.
  33. "Reza Dana, MD, MSc, MPH, Receives Kersley Medal". eye.hms.harvard.edu. Retrieved 2019-11-10.
  34. "Roger F. Meyer Lectureship in Cornea | Ophthalmology | Michigan Medicine". Ophthalmology. 2017-08-28. Retrieved 2019-11-10.
  35. "Reza Dana Elected to Academia Ophthalmologica Internationalis". eye.hms.harvard.edu. Retrieved 2019-11-10.
  36. "Honorary Lectures + ICO Medal Winners | Eye Doctors ©2019". entertainment.ie. Retrieved 2019-11-10.
  37. "Dr. Reza Dana to Receive 2016 Endre A. Balazs Prize". eye.hms.harvard.edu. Retrieved 2019-11-10.
  38. "The 121st Annual Meeting of the Japanese Ophthalmological Society". convention.jtbcom.co.jp. Retrieved 2019-11-10.
  39. "Reza Dana receives Senior Achievement Award from AAO". eye.hms.harvard.edu. Retrieved 2019-11-10.
  40. Jurkunas, Ula. "30th Biennial Cornea Conference". Grantome.
  41. "Dr. Reza Dana to receive Friedenwald Award from the Association for Research in Vision and Ophthalmology". eye.hms.harvard.edu. Retrieved 2019-11-10.
  42. "Reza Dana, MD, MSc, MPH, Awarded Research to Prevent Blindness Stein Innovation Award". eye.hms.harvard.edu. Retrieved 2019-11-10.
  43. "2019 Ellis Island Medal of Honor Recipients". eihonors.org. Retrieved 2019-11-10.
  44. "Reza Dana". The Ophthalmologist. Retrieved 2020-04-02.
  45. "Reza Dana, MD, MSc, MPH". eye.hms.harvard.edu. Retrieved 2019-11-10.
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