Rachel Tanner

Rachel Tanner is an immunologist working at the Jenner Institute at the University of Oxford. She won the 'Women of the Future' Award for Science in 2019.[1][2]

Research

Tanner researches tuberculosis with a focus on immune correlates of protection and the host immune response to TB vaccination.[3] She has worked extensively on in vitro functional assays for vaccine testing to reduce the number of animals used in 'challenge' or infection experiments, and has led an NC3Rs funded project to transfer one such assay internationally.[4] Her research interests also include the specific and non-specific effects of the BCG vaccine across different populations, and development of a vaccine against Mycobacterium bovis in cattle.[5] Initial research was on HIV vaccines with the Centre for HIV-AIDS Vaccine Immunology (CHAVI) at the Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, but since her work has moved to TB.[6]

Career

Tanner was awarded an MA in Biological Sciences from Wadham College and a DPhil in Clinical Medicine from St Cross College, University of Oxford, and was funded in the latter by the Universities Federation for Animal Welfare (UFAW).[7] She was a Fulford Junior Research Fellow of Somerville College from 2017-2019. She is a lecturer in Human Sciences at Wadham College and a VALIDATE Fellow.[8]

Publications
  • The cross-species mycobacterial growth inhibition assay (MGIA)[9]
  • The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays[10]
  • Replacing, reducing and refining the use of animals in tuberculosis vaccine research[11]
  • In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy[12]
  • Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis[13]
  • T-cell activation is an immune correlate of risk in BCG vaccinated infants[14]
  • Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A[15]
  • Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG[16]

References
  1. Reporters, Telegraph (2019-11-08). "Meet the 15 'women of the future' you need to know". The Telegraph. ISSN 0307-1235. Retrieved 2019-11-08.
  2. "2019". Women of the Future Awards. Retrieved 2019-11-08.
  3. https://www.jenner.ac.uk/dr-rachel-tanner
  4. "Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response | NC3Rs". www.nc3rs.org.uk. Retrieved 2019-11-08.
  5. https://www.jenner.ac.uk/dr-rachel-tanner
  6. "Rachel Tanner | Veterinary Vaccinology Network". www.vetvaccnet.ac.uk. Retrieved 2019-11-08.
  7. "UFAW 3Rs Liaison Studentship 2012-2015". www.ufaw.org.uk. Retrieved 2019-11-08.
  8. https://www.validate-network.org/fellowship-rachel-tanner
  9. Brennan, Michael J.; Tanner, Rachel; Morris, Sheldon; Scriba, Thomas J.; Achkar, Jacqueline M.; Zelmer, Andrea; Hokey, David A.; Izzo, Angelo; Sharpe, Sally; Williams, Ann; Penn-Nicholson, Adam (2017). "The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project". Clinical and Vaccine Immunology. 24 (9). doi:10.1128/CVI.00142-17. ISSN 1556-679X. PMC 5585695. PMID 28701467.
  10. Tanner, Rachel; O'Shea, Matthew K.; White, Andrew D.; Müller, Julius; Harrington-Kandt, Rachel; Matsumiya, Magali; Dennis, Mike J.; Parizotto, Eneida A.; Harris, Stephanie; Stylianou, Elena; Naranbhai, Vivek (2017). "The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays". Scientific Reports. 7: 43478. doi:10.1038/srep43478. ISSN 2045-2322. PMC 5335253. PMID 28256545.
  11. Tanner, Rachel; McShane, Helen (2017). "Replacing, reducing and refining the use of animals in tuberculosis vaccine research". ALTEX. 34 (1): 157–166. doi:10.14573/altex.1607281. ISSN 1868-596X. PMID 27667476.
  12. Tanner, Rachel; O’Shea, Matthew K.; Fletcher, Helen A.; McShane, Helen (2016-09-07). "In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy". Vaccine. 34 (39): 4656–4665. doi:10.1016/j.vaccine.2016.07.058. ISSN 0264-410X. PMID 27527814.
  13. Zelmer, Andrea; Tanner, Rachel; Stylianou, Elena; Damelang, Timon; Morris, Sheldon; Izzo, Angelo; Williams, Ann; Sharpe, Sally; Pepponi, Ilaria; Walker, Barry; Hokey, David A. (2016-08-12). "A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis". BMC Infectious Diseases. 16: 412. doi:10.1186/s12879-016-1751-4. ISSN 1471-2334. PMC 4983071. PMID 27519524.
  14. Fletcher, Helen A.; Snowden, Margaret A.; Landry, Bernard; Rida, Wasima; Satti, Iman; Harris, Stephanie A.; Matsumiya, Magali; Tanner, Rachel; O’Shea, Matthew K.; Dheenadhayalan, Veerabadran; Bogardus, Leah (2016-04-12). "T-cell activation is an immune correlate of risk in BCG vaccinated infants". Nature Communications. 7 (1): 1–11. doi:10.1038/ncomms11290. ISSN 2041-1723. PMID 27068708.
  15. Tanner, Rachel Kakalacheva, Kristina Miller, Ellen Pathan, Ansar A Chalk, Rod Sander, Clare R Scriba, Tom Tameris, Michelle Hawkridge, Tony Mahomed, Hassan Hussey, Greg Hanekom, Willem Checkley, Anna McShane, Helen Fletcher, Helen A (2014-12-03). Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. BioMed Central Ltd. OCLC 898756731.CS1 maint: multiple names: authors list (link)
  16. Fletcher, Helen A.; Tanner, Rachel; Wallis, Robert S.; Meyer, Joel; Manjaly, Zita-Rose; Harris, Stephanie; Satti, Iman; Silver, Richard F.; Hoft, Dan; Kampmann, Beate; Walker, K. Barry (2013). "Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG". Clinical and Vaccine Immunology. 20 (11): 1683–1689. doi:10.1128/CVI.00427-13. ISSN 1556-679X. PMC 3837779. PMID 23986316.
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