MST4

Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene.[5]

STK26
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTK26, MASK, MST4, serine/threonine protein kinase 26, serine/threonine kinase 26
External IDsOMIM: 300547 MGI: 1917665 HomoloGene: 84402 GeneCards: STK26
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq26.2Start132,023,302 bp[1]
End132,075,943 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51765

70415

Ensembl

ENSG00000134602

ENSMUSG00000031112

UniProt

Q9P289

Q99JT2

RefSeq (mRNA)

NM_001042452
NM_001042453
NM_016542

NM_133729
NM_001313744

RefSeq (protein)

NP_001035917
NP_001035918
NP_057626

NP_001300673
NP_598490

Location (UCSC)Chr X: 132.02 – 132.08 MbChr X: 50.84 – 50.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[5]

Interactions

RP6-213H19.1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000134602 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031112 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4".
  6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.