REXO4

REXO4
Identifiers
Aliases	REXO4, REX4, XPMC2, XPMC2H, REX4 homolog, 3'-5' exonuclease
External IDs	OMIM: 602930 MGI: 2684957 HomoloGene: 133948 GeneCards: REXO4
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	133,418,096 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	26,964,386 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • nuclease activity; • exonuclease activity; • hydrolase activity; • nucleic acid binding; • RNA binding; • single-stranded DNA binding; • GO:0001105 transcription coactivator activity; • endonuclease activity; • 3'-5' exonuclease activity;
Cellular component	• nucleolus; • cell nucleus; • nuclear speck;
Biological process	• regulation of transcription, DNA-templated; • nucleic acid phosphodiester bond hydrolysis; • non-recombinational repair; • DNA catabolic process, endonucleolytic; • DNA catabolic process, exonucleolytic; • rRNA processing; • positive regulation of transcription from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	57109
	227656
	ENSG00000280706; ENSG00000148300
	ENSMUSG00000052406
	Q9GZR2
	Q6PAQ4
	NM_001279349; NM_001279350; NM_001279351; NM_020385
	NM_207234; NM_001362876
	NP_001266278; NP_001266279; NP_001266280; NP_065118
	NP_997117; NP_001349805
	Wikidata
View/Edit Human	View/Edit Mouse

RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.[5][6]

References

ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052406 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.
"Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".

Montano MM, Wittmann BM, Bianco NR (2000). "Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity". J. Biol. Chem. 275 (44): 34306–13. doi:10.1074/jbc.M003880200. PMID 10908561.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052406 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9325058-5] Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.

[entrez-6] "Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".

REXO4

References

Further reading