RCC2

RCC2
Identifiers
Aliases	RCC2, TD-60, regulator of chromosome condensation 2
External IDs	OMIM: 609587 MGI: 1919784 HomoloGene: 10282 GeneCards: RCC2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	17,439,677 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	140,723,220 bp[2]
Gene ontology
Molecular function	• Rac GTPase binding; • protein domain specific binding; • microtubule binding; • small GTPase binding; • GO:0001948 protein binding; • protein kinase binding; • RNA binding; • guanyl-nucleotide exchange factor activity;
Cellular component	• cytoplasm; • cytosol; • early endosome membrane; • membrane; • cell membrane; • spindle; • chromosome, centromeric core domain; • chromosome; • mitotic spindle midzone; • midbody; • nucleolus; • microtubule; • chromosome, centromeric region; • cytoskeleton; • cell nucleus;
Biological process	• regulation of cell migration; • activation of GTPase activity; • establishment of protein localization; • cell division; • chromosome passenger complex localization to kinetochore; • positive regulation of attachment of spindle microtubules to kinetochore; • focal adhesion assembly; • negative regulation of GTPase activity; • regulation of ruffle assembly; • integrin-mediated signaling pathway; • positive regulation of G2/M transition of mitotic cell cycle; • cell cycle; • negative regulation of substrate adhesion-dependent cell spreading; • regulation of fibroblast migration; • negative regulation of focal adhesion assembly; • sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	55920
	108911
	ENSG00000281540; ENSG00000179051
	ENSMUSG00000040945
	Q9P258
	Q8BK67
	NM_018715; NM_001136204
	NM_173867
	NP_001129676; NP_061185; NP_001129676.1; NP_061185.1
	NP_776292
	Wikidata
View/Edit Human	View/Edit Mouse

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.[5][6][7]

Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.[6] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.[8][9]

References

ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040945 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
"Entrez Gene: RCC2 regulator of chromosome condensation 2".
Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.
Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. doi:10.1126/science.1148980. PMID 18218899.

External links

Overview of all the structural information available in the PDB for UniProt: Q9P258 (Protein RCC2) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] ENSG00000179051 GRCh38: Ensembl release 89: ENSG00000281540, ENSG00000179051 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040945 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid12919680-6] Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL (Aug 2003). "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell. 5 (2): 295–307. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.

[entrez-7] "Entrez Gene: RCC2 regulator of chromosome condensation 2".

[pmid15249581-8] Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (July 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304. PMID 15249581.

[pmid18218899-9] Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science. 319 (5862): 469–72. doi:10.1126/science.1148980. PMID 18218899.

RCC2

Function

References

Further reading

External links