RBM15

RBM15
Identifiers
Aliases	RBM15, OTT, OTT1, SPEN, RNA binding motif protein 15, Putative RNA-binding protein 15
External IDs	OMIM: 606077 MGI: 2443205 HomoloGene: 23383 GeneCards: RBM15
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	110,346,681 bp[1]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • nucleic acid binding; • RNA binding; • mRNA binding;
Cellular component	• nuclear speck; • nuclear membrane; • membrane; • cell nucleus; • nucleoplasm; • nuclear envelope; • RNA N6-methyladenosine methyltransferase complex;
Biological process	• branching involved in blood vessel morphogenesis; • ventricular septum morphogenesis; • mRNA splicing, via spliceosome; • placenta blood vessel development; • viral process; • negative regulation of myeloid cell differentiation; • spleen development; • negative regulation of transcription, DNA-templated; • positive regulation of transcription of Notch receptor target; • regulation of alternative mRNA splicing, via spliceosome; • RNA methylation; • dosage compensation by inactivation of X chromosome; • thrombopoietin-mediated signaling pathway; • regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	64783
	229700
	ENSG00000162775
	n/a
	Q96T37
	Q0VBL3
	NM_001201545; NM_022768
	NM_001045807
	NP_001188474; NP_073605
	NP_001039272
	Wikidata
View/Edit Human	View/Edit Mouse

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene.[4][5][6] It is a RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs[7]

References

GRCh38: Ensembl release 89: ENSG00000162775 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691.
Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.
"Entrez Gene: RBM15 RNA binding motif protein 15".
"UniProtKB - Q96T37 (RBM15_HUMAN)". Retrieved 29 October 2018.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hsiao HH, Yang MY, Liu YC, et al. (2005). "RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient". Am. J. Hematol. 79 (1): 43–5. doi:10.1002/ajh.20298. PMID 15849773.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Lindtner S, Zolotukhin AS, Uranishi H, et al. (2007). "RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway". J. Biol. Chem. 281 (48): 36915–28. doi:10.1074/jbc.M608745200. PMID 17001072.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162775 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11431691-4] Ma Z, Morris SW, Valentine V, Li M, Herbrick JA, Cui X, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GC, Chan LC, Squire J, Scherer SW, Hitzler JK (Jun 2001). "Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia". Nat Genet. 28 (3): 220–1. doi:10.1038/90054. PMID 11431691.

[pmid11344311-5] Mercher T, Coniat MB, Monni R, Mauchauffe M, Nguyen Khac F, Gressin L, Mugneret F, Leblanc T, Dastugue N, Berger R, Bernard OA (May 2001). "Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia". Proc Natl Acad Sci U S A. 98 (10): 5776–9. doi:10.1073/pnas.101001498. PMC 33289. PMID 11344311.

[entrez-6] "Entrez Gene: RBM15 RNA binding motif protein 15".

[uniprot-7] "UniProtKB - Q96T37 (RBM15_HUMAN)". Retrieved 29 October 2018.

RBM15

References

Further reading