RASGRF2

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.[4]

RASGRF2
Identifiers
AliasesRASGRF2, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2
External IDsOMIM: 606614 MGI: 109137 HomoloGene: 2169 GeneCards: RASGRF2
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q14.1Start80,960,363 bp[1]
End81,230,162 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5924

19418

Ensembl

ENSG00000113319

n/a

UniProt

O14827

P70392

RefSeq (mRNA)

NM_006909

NM_009027

RefSeq (protein)

NP_008840

NP_033053

Location (UCSC)Chr 5: 80.96 – 81.23 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][4]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000113319 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2".
  5. "Binge Drinking Gene: RASGRF-2 Helps Explain Teenage Alcohol Abuse, Scientists Say". Huffington Post. 3 December 2012.

Further reading


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