RARS (gene)

Arginyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the RARS gene.[5][6]

RARS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRARS1, ArgRS, DALRD1, HLD9, arginyl-tRNA synthetase, arginyl-tRNA synthetase 1, RARS
External IDsOMIM: 107820 MGI: 1914297 HomoloGene: 68281 GeneCards: RARS1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q34Start168,486,451 bp[1]
End168,519,301 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

5917

104458

Ensembl

ENSG00000113643

ENSMUSG00000018848

UniProt

P54136

Q9D0I9

RefSeq (mRNA)

NM_002887

NM_025936

RefSeq (protein)

NP_002878

NP_080212

Location (UCSC)Chr 5: 168.49 – 168.52 MbChr 11: 35.81 – 35.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.[6]

Genetics

Mutations in RARS cause hypomyelination.[7]

Interactions

RARS (gene) has been shown to interact with QARS.[8]

References
  1. GRCh38: Ensembl release 89: ENSG00000113643 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018848 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Girjes AA, Hobson K, Chen P, Lavin MF (October 1995). "Cloning and characterization of cDNA encoding a human arginyl-tRNA synthetase". Gene. 164 (2): 347–50. doi:10.1016/0378-1119(95)00502-W. PMID 7590355.
  6. "Entrez Gene: RARS arginyl-tRNA synthetase".
  7. Wolf NI, Salomons GS, Rodenburg RJ, Pouwels PJ, Schieving JH, Derks TG, Fock JM, Rump P, van Beek DM, van der Knaap MS, Waisfisz Q (July 2014). "Mutations in RARS cause hypomyelination". Annals of Neurology. 76 (1): 134–9. doi:10.1002/ana.24167. PMID 24777941.
  8. Kim T, Park SG, Kim JE, Seol W, Ko YG, Kim S (July 2000). "Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex". The Journal of Biological Chemistry. 275 (28): 21768–72. doi:10.1074/jbc.M002404200. PMID 10801842.

Further reading
  • McCune SA, Yu PL, Nance WE (1977). "A genetic study of erythrocyte arginine-tRNA synthetase activity in man". Acta Geneticae Medicae et Gemellologiae. 26 (1): 21–7. doi:10.1017/S0001566000010151. PMID 562050.
  • Norcum MT (August 1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". The Journal of Biological Chemistry. 266 (23): 15398–405. PMID 1651330.
  • Wang HY, Pan F (1985). "Kinetic mechanism of arginyl-tRNA synthetase from human placenta". The International Journal of Biochemistry. 16 (12): 1379–85. doi:10.1016/0020-711X(84)90244-1. PMID 6530022.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Rho SB, Lee JS, Jeong EJ, Kim KS, Kim YG, Kim S (May 1998). "A multifunctional repeated motif is present in human bifunctional tRNA synthetase". The Journal of Biological Chemistry. 273 (18): 11267–73. doi:10.1074/jbc.273.18.11267. PMID 9556618.
  • Quevillon S, Robinson JC, Berthonneau E, Siatecka M, Mirande M (January 1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein". Journal of Molecular Biology. 285 (1): 183–95. doi:10.1006/jmbi.1998.2316. PMID 9878398.
  • Park SG, Jung KH, Lee JS, Jo YJ, Motegi H, Kim S, Shiba K (June 1999). "Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase". The Journal of Biological Chemistry. 274 (24): 16673–6. doi:10.1074/jbc.274.24.16673. PMID 10358004.
  • Kim T, Park SG, Kim JE, Seol W, Ko YG, Kim S (July 2000). "Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex". The Journal of Biological Chemistry. 275 (28): 21768–72. doi:10.1074/jbc.M002404200. PMID 10801842.
  • Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (October 2000). "Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases". The Journal of Biological Chemistry. 275 (41): 31682–8. doi:10.1074/jbc.M909965199. PMID 10913161.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
  • Ling C, Yao YN, Zheng YG, Wei H, Wang L, Wu XF, Wang ED (October 2005). "The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex". The Journal of Biological Chemistry. 280 (41): 34755–63. doi:10.1074/jbc.M413511200. PMID 16055448.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Bottoni A, Vignali C, Piccin D, Tagliati F, Luchin A, Zatelli MC, Uberti EC (August 2007). "Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines". Journal of Cellular Physiology. 212 (2): 293–7. doi:10.1002/jcp.21083. PMID 17443684.
  • Overview of all the structural information available in the PDB for UniProt: P54136 (Human Arginine--tRNA ligase, cytoplasmic) at the PDBe-KB.
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