RALY

RALY
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WF1
Identifiers
Aliases	RALY, HNRPCL2, P542, RALY heterogeneous nuclear ribonucleoprotein
External IDs	OMIM: 614663 MGI: 97850 HomoloGene: 7216 GeneCards: RALY
Gene location (Human)
Chr.	Chromosome 20 (human)[1]
End	34,108,308 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	154,867,261 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • nucleic acid binding; • GO:0001104 transcription cofactor activity; • RNA binding;
Cellular component	• catalytic step 2 spliceosome; • spliceosomal complex; • intracellular ribonucleoprotein complex; • cell nucleus;
Biological process	• mRNA splicing, via spliceosome; • mRNA processing; • RNA splicing; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • regulation of nucleic acid-templated transcription; • regulation of cholesterol homeostasis; • cholesterol homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	22913
	19383
	ENSG00000125970
	ENSMUSG00000027593
	Q9UKM9
	Q64012
	NM_007367; NM_016732
	NM_001139511; NM_001139512; NM_001139513; NM_023130
	NP_031393; NP_057951
	NP_001132983; NP_001132984; NP_001132985; NP_075619
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.[5][6]

In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.[6]

References

GRCh38: Ensembl release 89: ENSG00000125970 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027593 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)" (PDF). Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.
"Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary". Pituitary. 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Rhodes GH, Valbracht JR, Nguyen MD, Vaughan JH (1997). "The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein". J. Autoimmun. 10 (5): 447–54. doi:10.1006/jaut.1997.9996. PMID 9376072.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vaughan JH, Valbracht JR, Nguyen MD, et al. (1995). "Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1". J. Clin. Invest. 95 (3): 1306–15. doi:10.1172/JCI117781. PMC 441470. PMID 7533788.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125970 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027593 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10500250-5] Khrebtukova I, Kuklin A, Woychik RP, Michaud EJ (Nov 1999). "Alternative processing of the human and mouse raly genes(1)" (PDF). Biochim Biophys Acta. 1447 (1): 107–12. doi:10.1016/s0167-4781(99)00126-8. PMID 10500250.

[entrez-6] "Entrez Gene: RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))".

RALY

References

Further reading