RABAC1

RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.[5][6][7] It is highly conserved in eukaryotes.[5] The protein is localized to Golgi[8] and late endosomes,[9] where it plays a role in vesicular trafficking, lipid transport and cell migration.[10]

RABAC1
Identifiers
AliasesRABAC1, PRA1, PRAF1, YIP3, Rab acceptor 1
External IDsOMIM: 604925 MGI: 1201692 HomoloGene: 38182 GeneCards: RABAC1
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start41,956,681 bp[1]
End41,959,321 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10567

14470

Ensembl

ENSG00000105404

ENSMUSG00000003380

UniProt

Q9UI14

Q9Z0S9

RefSeq (mRNA)

NM_006423

NM_010261

RefSeq (protein)

NP_006414

NP_034391

Location (UCSC)Chr 19: 41.96 – 41.96 MbChr 7: 24.97 – 24.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family[5][11][12] and VAMP2.[12]

References
  1. GRCh38: Ensembl release 89: ENSG00000105404 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003380 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
  6. Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jun 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry. 275 (24): 18511–9. doi:10.1074/jbc.M909309199. PMID 10751420.
  7. "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)".
  8. Abdul-Ghani M, Gougeon PY, Prosser DC, Da-Silva LF, Ngsee JK (Mar 2001). "PRA isoforms are targeted to distinct membrane compartments". The Journal of Biological Chemistry. 276 (9): 6225–33. doi:10.1074/jbc.M009073200. PMID 11096102.
  9. Sivars U, Aivazian D, Pfeffer SR (Oct 2003). "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature. 425 (6960): 856–9. Bibcode:2003Natur.425..856S. doi:10.1038/nature02057. PMID 14574414.
  10. Liu HP, Wu CC, Kao HY, Huang YC, Liang Y, Chen CC, Yu JS, Chang YS (Mar 2011). "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Molecular & Cellular Proteomics. 10 (3): M900641–MCP200. doi:10.1074/mcp.M900641-MCP200. PMC 3047168. PMID 20592422.
  11. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  12. Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.

Further reading
  • Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.
  • Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC (Jan 2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon". Neuron. 25 (1): 203–14. doi:10.1016/S0896-6273(00)80883-1. PMID 10707984.
  • Figueroa C, Taylor J, Vojtek AB (Jul 2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases". The Journal of Biological Chemistry. 276 (30): 28219–25. doi:10.1074/jbc.M101763200. PMID 11335720.
  • Bucci C, De Gregorio L, Bruni CB (Aug 2001). "Expression analysis and chromosomal assignment of PRA1 and RILP genes". Biochemical and Biophysical Research Communications. 286 (4): 815–9. doi:10.1006/bbrc.2001.5466. PMID 11520070.
  • Evans DT, Tillman KC, Desrosiers RC (Jan 2002). "Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor". Journal of Virology. 76 (1): 327–37. doi:10.1128/JVI.76.1.327-337.2002. PMC 135700. PMID 11739697.
  • Blancou P, Evans DT, Desrosiers RC (Jun 2005). "PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation". The Journal of General Virology. 86 (Pt 6): 1785–90. doi:10.1099/vir.0.80873-0. PMID 15914857.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Fo CS, Coleman CS, Wallick CJ, Vine AL, Bachmann AS (Apr 2006). "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2)". Gene. 371 (1): 154–65. doi:10.1016/j.gene.2005.12.009. PMID 16481131.
  • Liu HP, Wu CC, Chang YS (Sep 2006). "PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1". The EMBO Journal. 25 (17): 4120–30. doi:10.1038/sj.emboj.7601282. PMC 1560356. PMID 16917502.
  • Kim JT, Cho MY, Choi SC, Kim JW, Chae SK, Yoon DY, Kim JW, Lim JS (Oct 2006). "Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin". Biochemical and Biophysical Research Communications. 349 (1): 200–8. doi:10.1016/j.bbrc.2006.08.026. PMID 16930546.
  • Dickison VM, Richmond AM, Abu Irqeba A, Martak JG, Hoge SC, Brooks MJ, Othman MI, Khanna R, Mears AJ, Chowdhury AY, Swaroop A, Ogilvie JM (2012). "A role for prenylated rab acceptor 1 in vertebrate photoreceptor development". BMC Neuroscience. 13: 152. doi:10.1186/1471-2202-13-152. PMC 3576285. PMID 23241222.
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