RAB7B

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[5]

RAB7B
Identifiers
AliasesRAB7B, RAB7, member RAS oncogene family
External IDsMGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.1Start205,976,740 bp[1]
End206,003,461 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

338382

226421

Ensembl

ENSG00000276600

ENSMUSG00000052688

UniProt

Q96AH8

Q8VEA8

RefSeq (mRNA)

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

RefSeq (protein)

NP_001157994
NP_001291768
NP_796377

NP_001298025
NP_663484

Location (UCSC)Chr 1: 205.98 – 206 MbChr 1: 131.69 – 131.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[6] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000276600 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000052688 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907.
  6. Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780.

Further reading


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