R-spondin 2

R-spondin 2 also known as roof plate-specific spondin-2 is a protein that in humans that is encoded by the RSPO2 gene.[5]

RSPO2
Identifiers
AliasesRSPO2, CRISTIN2, R-spondin 2, TETAMS2, HHRRD
External IDsOMIM: 610575 MGI: 1922667 HomoloGene: 18235 GeneCards: RSPO2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q23.1Start107,899,316 bp[1]
End108,083,642 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

340419

239405

Ensembl

ENSG00000147655

ENSMUSG00000051920

UniProt

Q6UXX9

Q8BFU0

RefSeq (mRNA)

NM_001282863
NM_178565
NM_001317942

NM_172815
NM_001357956
NM_001357957

RefSeq (protein)

NP_001269792
NP_001304871
NP_848660

NP_766403
NP_001344885
NP_001344886

Location (UCSC)Chr 8: 107.9 – 108.08 MbChr 15: 43.02 – 43.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

R-spondin 2 synergizes with Wnt to activate beta-catenin.[6][7] RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.[8]

In dogs, a variant on the Rspo2 gene is associated moustache and eyebrow thickness.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000147655 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051920 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: R-spondin 2".
  6. Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD (January 2006). "R-Spondin proteins: a novel link to beta-catenin activation". Cell Cycle. 5 (1): 23–6. doi:10.4161/cc.5.1.2305. PMID 16357527.
  7. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (October 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Dev. Cell. 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841.
  8. Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK (2011). "The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal–mesenchymal interaction". Developmental Biology. 352 (1): 1–13. doi:10.1016/j.ydbio.2011.01.004. PMC 3089906. PMID 21237142.
  9. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA (October 2009). "Coat variation in the domestic dog is governed by variants in three genes". Science. 326 (5949): 150–3. Bibcode:2009Sci...326..150C. doi:10.1126/science.1177808. PMC 2897713. PMID 19713490.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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