Pseudoprotease

Pseudoproteases are catalytically-deficient pseudoenzyme variants of proteases that are represented across the kingdoms of life.[1][2]

Comparison of Azurocidin 1 structure (pseudoprotease) to Chymotrypsin (functional protease) of same superfamily

Examples
Superfamilies containing pseudoenzymes with inactive triads [3]
Superfamily Families containing pseudoenzymes Examples
CA clan C1, C2, C19 Calpamodulin
CD clan C14 CFLAR
SC clan S9, S33 Neuroligin
SK clan S14 ClpR
SR clan S60 Serotransferrin domain 2
ST clan S54 RHBDF1
PA clan S1 Azurocidin 1
PB clan T1 PSMB3

See also

References
  1. Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function". Biochemical Journal. 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN 1470-8728. PMID 25940733.
  2. Todd AE, Orengo CA, Thornton JM (October 2002). "Sequence and structural differences between enzyme and nonenzyme homologs". Structure. 10 (10): 1435–51. doi:10.1016/s0969-2126(02)00861-4. PMID 12377129.
  3. Fischer, Katja; Reynolds, Simone L. (2015-05-15). "Pseudoproteases: mechanisms and function". Biochemical Journal. 468 (1): 17–24. doi:10.1042/BJ20141506. ISSN 1470-8728. PMID 25940733.


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