Prolonged grief disorder

PGD symptoms have been associated with:

• Elevated rates of suicidal ideation and attempts[3]
• Cancer[4]
• Immunological dysfunction[5]
• Hypertension[4]
• Cardiac events[4]
• Functional impairment[6][4]
• Adverse health behaviors[4]
• Reduced quality of life in adults[7][4][3][8][9][10] and in children[5]
• Increased health service use and sick leave[11]

Known risk factors include one-time and ongoing events and conditions:

• Miscarriage[12]
• Childhood separation anxiety[13]
• Controlling parents[14]
• Parental abuse or death[15]
• Close kinship relationship to the deceased (e.g., parents)[16][17]
• Insecure attachment styles[18]
• Emotional dependency[18][19]
• Lack of preparation for death[20][21]
• Death in hospital[22]
• No shortened rapid eye movement (REM) latency[23]
• Activation of the nucleus accumbens[24]

These risk factors and clinical correlates have been shown to relate to PGD symptoms and not symptoms of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and generalized anxiety disorder (GAD).[13][23]

Factor analytic studies have determined that the symptoms of PGD form a unitary construct that is separate from symptoms of bereavement-related depression and anxiety.[6][6][7][25][26][3][27][28][29][30][31] Extensive research has been conducted to identify and isolate the symptoms that constitute PGD and distinguish it from diagnostic "nearest neighbors" such as Major Depressive Disorder or Posttraumatic Stress Disorder.[6][7][25][26][3][27][29][30][31] These analyses integrate clinical insights with rigorous empirical analysis to determine the set of symptoms that best indicate which bereaved survivors will be at risk of long term dysfunction and distress (e.g., suicidality, alcohol abuse, disability days, sleep impairment, quality of life impairment, high blood pressure, hospitalizations for serious medical events such as heart attacks).[6][7][4][3][8][9][10][32][11]

Prigerson et al. proposed diagnostic criteria for PGD for inclusion in the DSM-5 and ICD-11.[6]

The unique symptom profile and course of PGD requires targeted treatment. Randomized control trials (RCT) have proven tricyclic antidepressants alone or together with interpersonal psychotherapy ineffective in reducing PGD symptoms, while psychotherapy designed specifically for PGD has been proven to be beneficial.[34][35][36][37][38] Preliminary results of an online, self-management intervention to prevent PGD in recently bereaved individuals, in a study called "HEAL" (Healthy Experiences After Loss), are very promising.[39] A larger randomized controlled trial is being planned.

Out of the people surveyed who have experienced a loss, 10–20% display a prolonged and severe grief response.[6][33] Global incidence needs further investigation.

The DSM-IV and ICD-10 do not distinguish between normal and prolonged grief.[40][41] Based on numerous findings of maladaptive effects of prolonged grief, diagnostic criteria for PGD have been proposed for inclusion in the DSM-5 and ICD-11.[6][42]

The proposed diagnostic criteria were the result of statistical analysis of a set of criteria agreed upon by a panel of experts.[6][27] The analyses produced criteria that were the most accurate markers of bereaved individuals suffering from painful, persistent, destructive PGD.[6] The criteria for PGD have been validated and dozens of studies both internationally and domestically are being conducted, and published, that validate the PGD criteria in other cultures, kinship relationships to the deceased and causes of death (e.g., earthquakes, tsunami, war, genocide, fires, bombings, palliative and acute care settings).[43][44]

Recognizing prolonged grief as a disorder would allow it to be better understood, detected, studied and treated. Insurance companies would also be more likely reimburse its care. On the other hand, inclusion of PGD in the DSM-5 and ICD-11 may be misunderstood as the medicalization of grief, reducing its dignity, turning love into pathology and implying that survivors should quickly forget and "get over" the loss. Bereaved persons may be insulted by having their distress labeled as a mental disorder. While this stigmatization would not be the intent, it might be an unintended consequence. In spite of this concern, studies have shown that nearly all bereaved individuals who met the criteria for PGD were receptive to treatment and their families relieved to know they had a recognizable syndrome.[45]