Phosphopantetheine

Phosphopantetheine, also known as 4'-Phosphopantetheine, is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.[1] It is also present in formyltetrahydrofolate dehydrogenase.[2]

Phosphopantetheine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
DrugBank
MeSH phosphopantetheine
UNII
Properties
C11H23N2O7PS
Molar mass 358.349 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Functions

Phosphopantetheine fulfills two demands.

  • First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
  • Second, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

See also

References

  1. Elovson J, Vagelos PR (July 1968). "Acyl carrier protein. X. Acyl carrier protein synthetase". J. Biol. Chem. 243 (13): 3603–11. PMID 4872726.
  2. Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA (January 2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.


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