Pendetide

Pendetide (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K).[1]

Pendetide
Names
IUPAC name
N6-[N-[2-[[2-[Bis(carboxymethyl)amino]ethyl](carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl]-N2-(N-glycyl-L-tyrosyl)-L-lysine
Identifiers
3D model (JSmol)
ChemSpider
UNII
Properties
C31H47N7O14
Molar mass 741.318 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Use

The following monoclonal antibodies are linked to pendetide to chelate a radionuclide, indium-111. The antibodies selectively bind to certain tumour cells, and the radioactivity is then used for imaging of the tumours.

References

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.