Pam Dawber

Dawber's professional breakthrough came when Marshall chose her, despite her having relatively little acting experience and not having auditioned for the part, as one of the two title characters of the ABC sitcom Mork & Mindy, which ran from 1978 to 1982. She portrayed Mindy McConnell, the comedic foil and eventual love interest for the extraterrestrial Mork from the planet Ork, played by a then-unknown Robin Williams. The show was extremely popular in its debut season, when it averaged at number three in the Nielsen ratings for the year.[6] The only major difficulty for her on set was that she often found it impossible to maintain the proper composure in character in the face of her co-star's comedic talent. Also, pressure came from the TV network to sexualize her character as the series progressed, which Dawber successfully resisted, with Williams' support.

Dawber sang in a 1980s Los Angeles Civic Light Opera production of Gilbert & Sullivan's The Pirates of Penzance, based on the Joseph Papp/New York Shakespeare Festival production. Her role, as Mabel, had been played by Linda Ronstadt in the New York run of the show.

From 1986 to 1988, Dawber again had the title role in a television series, playing Samantha Russell in the CBS sitcom My Sister Sam, co-starring Rebecca Schaeffer. The series was a success in its first season, but it suffered a massive ratings drop in its second after moving to Saturday night. My Sister Sam left the air in April 1988, with half of the second season's episodes never airing on CBS, but eventually airing (along with all previous episodes) on USA Network.

In July 1989, over a year after the show's cancellation, Schaeffer was shot and killed by Robert John Bardo, an obsessed fan, in front of her apartment. Dawber reported being "devastated" by her former co-star's death.[7] Dawber and her other surviving My Sister Sam co-stars, Joel Brooks, David Naughton and Jenny O'Hara, reunited to film a public service announcement about violence prevention, and Dawber herself became a gun control advocate. With the birth of her second child, she left the industry for family reasons and acted sporadically during the 1990s.

Although mostly known for her television work, Dawber has starred in several films, including the comedy movie Stay Tuned (1992) with John Ritter and the period movie I'll Remember April (1999), alongside her husband Mark Harmon.

In 1997, Dawber starred in the television series Life... and Stuff.[8]

In 2014, she reunited with Robin Williams on his comedy series The Crazy Ones as a love interest of Williams's character.[9][10] But this reunion failed to boost the show's ratings, and it was cancelled shortly afterwards. Williams, already suffering from Lewy body disease by this time, died by suicide later that year.

Dawber is a national spokeswoman for Big Brothers Big Sisters of America. Garry K. Marshall, the film-and-television comedy writer-producer-director who, as noted above, had made possible Dawber's professional breakthrough, died in 2016. In that year, Dawber made a guest appearance on The Odd Couple in a tribute episode to Marshall, along with other such Marshall alums as Ron Howard, Garry's own sister Penny Marshall, Cindy Williams, Don Most, Anson Williams and Marion Ross.