PYGO2

PYGO2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2XB1, 4UP0, 4UP5
Identifiers
Aliases	PYGO2, 1190004M21Rik, pygopus family PHD finger 2
External IDs	OMIM: 606903 MGI: 1916161 HomoloGene: 44519 GeneCards: PYGO2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	154,963,853 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	89,435,128 bp[2]
Gene ontology
Molecular function	• histone binding; • metal ion binding; • GO:0001948 protein binding; • chromatin binding; • histone acetyltransferase regulator activity;
Cellular component	• nucleoplasm; • cell nucleus; • beta-catenin-TCF complex;
Biological process	• palate development; • regulation of histone H3-K4 methylation; • in utero embryonic development; • regulation of mammary gland epithelial cell proliferation; • positive regulation of chromatin binding; • mammary gland development; • brain development; • lens development in camera-type eye; • developmental growth; • regulation of histone acetylation; • spermatid development; • canonical Wnt signaling pathway; • beta-catenin-TCF complex assembly; • kidney development; • spermatid nucleus differentiation; • post-embryonic development; • Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	90780
	68911
	ENSG00000163348
	ENSMUSG00000047824
	Q9BRQ0
	n/a
	NM_138300
	NM_001293763; NM_001293766; NM_001293767; NM_001293768; NM_026869
	NP_612157
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000163348 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047824 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739.
"Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

Kramps T, Peter O, Brunner E, et al. (2002). "Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex". Cell. 109 (1): 47–60. doi:10.1016/S0092-8674(02)00679-7. PMID 11955446.
Pilvar P, Chalbatani GM, Forghanifard MM, Mahmoodzadeh H, Besanjideh P (2017). "The evaluation of SALL4 gene silencing, and effects on PYGO2, twist and maml genes in esophageal squamous cell carcinoma". Int J Pharm Sci Res. 8 (7): 1000–07. doi:10.13040/IJPSR.0975-8232.8(7).1000-07.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Townsley FM, Thompson B, Bienz M (2004). "Pygopus residues required for its binding to Legless are critical for transcription and development". J. Biol. Chem. 279 (7): 5177–83. doi:10.1074/jbc.M309722200. PMID 14612447.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Popadiuk CM, Xiong J, Wells MG, et al. (2006). "Antisense suppression of pygopus2 results in growth arrest of epithelial ovarian cancer". Clin. Cancer Res. 12 (7 Pt 1): 2216–23. doi:10.1158/1078-0432.CCR-05-2433. PMID 16609037.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Hoffmans R, Basler K (2007). "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling". Mech. Dev. 124 (1): 59–67. doi:10.1016/j.mod.2006.09.006. PMID 17113272.
Andrews PG, Lake BB, Popadiuk C, Kao KR (2007). "Requirement of Pygopus 2 in breast cancer". Int. J. Oncol. 30 (2): 357–63. doi:10.3892/ijo.30.2.357. PMID 17203217.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163348 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047824 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11988739-5] Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M (May 2002). "A new nuclear component of the Wnt signalling pathway". Nat Cell Biol. 4 (5): 367–73. doi:10.1038/ncb786. PMID 11988739.

[entrez-6] "Entrez Gene: PYGO2 pygopus homolog 2 (Drosophila)".

PYGO2

References

Further reading