PSCDBP

CYTIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z17
Identifiers
Aliases	CYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP, cytohesin 1 interacting protein
External IDs	OMIM: 604448 MGI: 2183535 HomoloGene: 3167 GeneCards: CYTIP
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	157,488,961 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	58,195,532 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• cytoplasm; • endosome; • cell cortex; • early endosome; • nucleoplasm; • cytosol;
Biological process	• regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	9595
	227929
	ENSG00000115165
	ENSMUSG00000026832
	O60759
	Q91VY6
	NM_004288
	NM_139200
	NP_004279
	NP_631939
	Wikidata
View/Edit Human	View/Edit Mouse

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.[5][6][7][8]

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.[8]

References

GRCh38: Ensembl release 89: ENSG00000115165 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026832 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.
Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115.
Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.
"Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Boehm T, Hofer S, Winklehner P, et al. (2003). "Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration". EMBO J. 22 (5): 1014–24. doi:10.1093/emboj/cdg101. PMC 150334. PMID 12606567.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Chen Q, Coffey A, Bourgoin SG, Gadina M (2006). "Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway". J. Biol. Chem. 281 (29): 19985–94. doi:10.1074/jbc.M601629200. PMID 16702224.
MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115165 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026832 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8241278-5] Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.

[pmid10343115-6] Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 95. doi:10.1159/000015226. PMID 10343115.

[pmid11867758-7] Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.

[entrez-8] "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

PSCDBP

References

Further reading