PRX (gene)

Periaxin is a protein that in humans is encoded by the PRX gene.[5][6][7]

PRX
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRX, CMT4F, periaxin
External IDsOMIM: 605725 MGI: 108176 HomoloGene: 76542 GeneCards: PRX
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start40,393,766 bp[1]
End40,414,742 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57716

19153

Ensembl

ENSG00000105227

ENSMUSG00000053198

UniProt

Q9BXM0

O55103

RefSeq (mRNA)

NM_020956
NM_181882

NM_019412
NM_198048

RefSeq (protein)

NP_066007
NP_870998

NP_062285
NP_932165

Location (UCSC)Chr 19: 40.39 – 40.41 MbChr 7: 27.5 – 27.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The PRX gene encodes L- and S-periaxin, proteins of myelinating Schwann cells, and is mutated in Dejerine–Sottas syndrome (MIM 145900) and Charcot–Marie–Tooth disease type 4F (MIM 145900).[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000105227 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053198 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gillespie CS, Sherman DL, Fleetwood-Walker SM, Cottrell DF, Tait S, Garry EM, Wallace VC, Ure J, Griffiths IR, Smith A, Brophy PJ (Jun 2000). "Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice". Neuron. 26 (2): 523–31. doi:10.1016/S0896-6273(00)81184-8. PMID 10839370.
  6. Gillespie CS, Lee M, Fantes JF, Brophy PJ (Jul 1997). "The gene encoding the Schwann cell protein periaxin localizes on mouse chromosome 7 (Prx)". Genomics. 41 (2): 297–8. doi:10.1006/geno.1997.4630. PMID 9143514.
  7. "Entrez Gene: PRX periaxin".

Further reading


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