POLDIP2

POLDIP2
Identifiers
Aliases	POLDIP2, PDIP38, POLD4, p38, polymerase (DNA) delta interacting protein 2, DNA polymerase delta interacting protein 2
External IDs	OMIM: 611519 MGI: 1915061 HomoloGene: 9201 GeneCards: POLDIP2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	28,357,527 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	78,522,736 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding;
Cellular component	• mitochondrial nucleoid; • mitochondrion; • cell nucleus;
Biological process	• mitochondrion morphogenesis; • negative regulation of macroautophagy; • positive regulation of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	26073
	67811
	ENSG00000004142
	ENSMUSG00000001100
	Q9Y2S7
	Q91VA6
	NM_015584; NM_001290145
	NM_026389
	NP_001277074; NP_056399
	NP_080665
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase delta-interacting protein 2 is an enzyme that in humans is encoded by the POLDIP2 gene.[5][6]

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[6]

Interactions

POLDIP2 has been shown to interact with PCNA.[5]

References

GRCh38: Ensembl release 89: ENSG00000004142 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001100 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
"Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2".

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Xie B, Li H, Wang Q, et al. (2005). "Further characterization of human DNA polymerase delta interacting protein 38". J. Biol. Chem. 280 (23): 22375–84. doi:10.1074/jbc.M414597200. PMID 15811854.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Klaile E, Müller MM, Kannicht C, et al. (2007). "The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38". J. Biol. Chem. 282 (36): 26629–40. doi:10.1074/jbc.M701807200. PMID 17623671.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004142 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001100 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12522211-5] Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.

[entrez-6] "Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2".

POLDIP2

Interactions

References

Further reading