PLVAP

PLVAP
Identifiers
Aliases	PLVAP, FELS, PV-1, PV1, gp68, plasmalemma vesicle associated protein, DIAR10
External IDs	OMIM: 607647 MGI: 1890497 HomoloGene: 10578 GeneCards: PLVAP
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	17,377,342 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	71,511,752 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • protein homodimerization activity;
Cellular component	• cytoplasm; • perinuclear region of cytoplasm; • caveola; • integral component of membrane; • cell surface; • cell membrane; • extracellular exosome; • membrane;
Biological process	• tumor necrosis factor-mediated signaling pathway; • protein kinase C signaling; • MAPK cascade; • positive regulation of cellular extravasation; • developmental process;
	Sources:Amigo / QuickGO
Orthologs
	83483
	84094
	ENSG00000130300
	ENSMUSG00000034845
	Q9BX97
	Q91VC4
	NM_031310
	NM_032398
	NP_112600
	NP_115774
	Wikidata
View/Edit Human	View/Edit Mouse

Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000130300 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034845 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.
"Entrez Gene: PLVAP plasmalemma vesicle associated protein".

Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170.
Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130300 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034845 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11401446-5] Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.

[entrez-6] "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

PLVAP

References

Further reading