PLA2G2D

PLA2G2D
Identifiers
Aliases	PLA2G2D, PLA2IID, SPLASH, sPLA2-IID, sPLA2S, phospholipase A2 group IID
External IDs	OMIM: 605630 MGI: 1341796 HomoloGene: 7892 GeneCards: PLA2G2D
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	20,119,566 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	138,782,046 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• calcium ion binding; • phospholipase A2 activity; • heparin binding; • metal ion binding; • heparan sulfate proteoglycan binding; • hydrolase activity; • phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); • phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine); • phospholipid binding; • calcium-dependent phospholipase A2 activity;
Cellular component	• extracellular region;
Biological process	• phosphatidic acid biosynthetic process; • phosphatidylserine acyl-chain remodeling; • phosphatidylethanolamine acyl-chain remodeling; • CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; • lipid metabolism; • phosphatidylinositol acyl-chain remodeling; • lipid catabolic process; • negative regulation of T cell proliferation; • phosphatidylglycerol acyl-chain remodeling; • inflammatory response; • negative regulation of T cell activation; • phosphatidylcholine acyl-chain remodeling; • phospholipid metabolic process; • arachidonic acid secretion;
	Sources:Amigo / QuickGO
Orthologs
	26279
	18782
	ENSG00000117215
	ENSMUSG00000041202
	Q9UNK4
	Q9WVF6
	NM_012400; NM_001271814
	NM_011109; NM_001347230
	NP_001258743; NP_036532
	NP_001334159; NP_035239
	Wikidata
View/Edit Human	View/Edit Mouse

Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000117215 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041202 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K (Sep 1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s". J Biol Chem. 274 (35): 24973–9. doi:10.1074/jbc.274.35.24973. PMID 10455175.
"Entrez Gene: PLA2G2D phospholipase A2, group IID".

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochem. Cell Biol. 82 (1): 1–17. doi:10.1139/o03-080. PMID 15052324.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Shakhov AN, Rubtsov AV, Lyakhov IG, et al. (2001). "SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency". Genes Immun. 1 (3): 191–9. doi:10.1038/sj.gene.6363659. PMID 11196711.
Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Eckey R, Menschikowski M, Lattke P, Jaross W (2005). "Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA". Inflammation. 28 (2): 59–65. doi:10.1023/B:IFLA.0000033021.44105.9c. PMID 15379211.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Takabatake N, Sata M, Inoue S, et al. (2006). "A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 172 (9): 1097–104. doi:10.1164/rccm.200503-319OC. PMID 16002569.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lindbom J, Ljungman AG, Tagesson C (2007). "Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide". Inflammation. 29 (2–3): 108–117. doi:10.1007/s10753-006-9007-x. PMID 16897354.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117215 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041202 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10455175-5] Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K (Sep 1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s". J Biol Chem. 274 (35): 24973–9. doi:10.1074/jbc.274.35.24973. PMID 10455175.

[entrez-6] "Entrez Gene: PLA2G2D phospholipase A2, group IID".

PLA2G2D

References

Further reading