PKIG

cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene.[5][6]

PKIG
Identifiers
AliasesPKIG, PKI-gamma, protein kinase (cAMP-dependent, catalytic) inhibitor gamma, cAMP-dependent protein kinase inhibitor gamma
External IDsOMIM: 604932 MGI: 1343086 HomoloGene: 5133 GeneCards: PKIG
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q13.12Start44,531,785 bp[1]
End44,624,247 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11142

18769

Ensembl

ENSG00000168734

ENSMUSG00000035268

UniProt

Q9Y2B9

O70139

RefSeq (mRNA)

NM_181805
NM_001281444
NM_001281445
NM_007066
NM_181804

RefSeq (protein)

NP_001268373
NP_001268374
NP_008997
NP_861520
NP_861521

Location (UCSC)Chr 20: 44.53 – 44.62 MbChr 2: 163.66 – 163.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant form of PKA inhibitors in various tissues. Three alternatively spliced transcript variants encoding the same protein have been reported.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000168734 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035268 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zheng L, Yu L, Tu Q, Zhang M, He H, Chen W, Gao J, Yu J, Wu Q, Zhao S (Jan 2001). "Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA". Biochem J. 349 (Pt 2): 403–7. doi:10.1042/0264-6021:3490403. PMC 1221161. PMID 10880337.
  6. "Entrez Gene: PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma".

Further reading


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