PIP5K1A

PIP5K1A
Identifiers
Aliases	PIP5K1A, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
External IDs	OMIM: 603275 MGI: 107929 HomoloGene: 93492 GeneCards: PIP5K1A
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	151,249,536 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	95,106,930 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • 1-phosphatidylinositol-4-phosphate 5-kinase activity; • kinase activity; • kinase binding; • GO:0001948 protein binding; • phosphatidylinositol phosphate kinase activity; • ATP binding; • 1-phosphatidylinositol-3-phosphate 5-kinase activity; • 1-phosphatidylinositol-5-kinase activity; • phosphatidylinositol-3,4-bisphosphate 5-kinase activity; • 1-phosphatidylinositol-3-phosphate 4-kinase activity;
Cellular component	• nuclear speck; • mRNA cleavage and polyadenylation specificity factor complex; • cell projection; • membrane; • focal adhesion; • ruffle; • cell membrane; • nucleoplasm; • ruffle membrane; • cell nucleus; • lamellipodium; • cytoplasm; • cytosol;
Biological process	• fibroblast migration; • actin cytoskeleton reorganization; • phosphatidylinositol metabolic process; • activation of GTPase activity; • phosphorylation; • keratinocyte differentiation; • focal adhesion assembly; • phospholipid biosynthetic process; • phagocytosis; • cell chemotaxis; • glycerophospholipid metabolic process; • ruffle assembly; • cell migration; • signal transduction; • phosphatidylinositol phosphorylation; • regulation of phosphatidylinositol 3-kinase signaling; • phosphatidylinositol biosynthetic process; • protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	8394
	18720
	ENSG00000143398
	ENSMUSG00000028126
	Q99755
	P70182
	NM_001135636; NM_001135637; NM_001135638; NM_003557; NM_001330689
	NM_001293707; NM_008847
	NP_001129108; NP_001129109; NP_001129110; NP_001317618; NP_003548
	NP_001280636; NP_032873
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha is an enzyme that in humans is encoded by the PIP5K1A gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000143398 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028126 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Loijens JC, Anderson RA (Jan 1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family". J Biol Chem. 271 (51): 32937–43. doi:10.1074/jbc.271.51.32937. PMID 8955136.
Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization". Cytogenet Cell Genet. 88 (3–4): 197–9. doi:10.1159/000015545. PMID 10828584.
"Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha".

Honda A, Nogami M, Yokozeki T, et al. (1999). "Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation". Cell. 99 (5): 521–32. doi:10.1016/S0092-8674(00)81540-8. PMID 10589680.
Jones DH, Morris JB, Morgan CP, et al. (2000). "Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment". J. Biol. Chem. 275 (18): 13962–6. doi:10.1074/jbc.C901019199. PMID 10747863.
Divecha N, Roefs M, Halstead JR, et al. (2000). "Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009. PMID 11032811.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Doughman RL, Firestone AJ, Wojtasiak ML, et al. (2003). "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling". J. Biol. Chem. 278 (25): 23036–45. doi:10.1074/jbc.M211397200. PMID 12682053.
Chang JD, Field SJ, Rameh LE, et al. (2004). "Identification and characterization of a phosphoinositide phosphate kinase homolog". J. Biol. Chem. 279 (12): 11672–9. doi:10.1074/jbc.M309721200. PMID 14701839.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kisseleva M, Feng Y, Ward M, et al. (2005). "The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Halstead JR, van Rheenen J, Snel MH, et al. (2006). "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis". Curr. Biol. 16 (18): 1850–6. doi:10.1016/j.cub.2006.07.066. PMID 16979564.
Im YJ, Perera IY, Brglez I, et al. (2007). "Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum". Plant Cell. 19 (5): 1603–16. doi:10.1105/tpc.107.051367. PMC 1913725. PMID 17496116.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143398 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028126 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8955136-5] Loijens JC, Anderson RA (Jan 1997). "Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family". J Biol Chem. 271 (51): 32937–43. doi:10.1074/jbc.271.51.32937. PMID 8955136.

[pmid10828584-6] Xie Y, Zhu L, Zhao G (Jun 2000). "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization". Cytogenet Cell Genet. 88 (3–4): 197–9. doi:10.1159/000015545. PMID 10828584.

[entrez-7] "Entrez Gene: PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha".

PIP5K1A

References

Further reading