PEG 400
PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.
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| Names | |
|---|---|
| IUPAC name
Polyethylene glycol | |
| Identifiers | |
| ChemSpider |
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| Properties | |
| C2nH4n+2On+1, n = 8.2 to 9.1 | |
| Molar mass | 380-420 g/mol |
| Density | 1.128 g/cm3 |
| Melting point | 4 to 8 °C (39 to 46 °F; 277 to 281 K) |
| Viscosity | 90.0 cSt at 25 °C, 7.3 cSt at 99 °C |
| Hazards | |
| Flash point | 238 °C (460 °F; 511 K) |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
30 mL/kg, orally in rats |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
Chemical properties
PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG400 in the hexane layer per 1 million parts of PEG 400 in the water layer.[1]
PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.
References
- T. Y. Ma; D. Hollander; P. Krugliak; K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46. PMID 2293598.
- The Merck Index, 11th Edition
- Handbook of Pharmaceutical Excipients
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