PCLKC

CDHR2
Identifiers
Aliases	CDHR2, PCDH24, PCLKC, cadherin related family member 2
External IDs	MGI: 2687323 HomoloGene: 134510 GeneCards: CDHR2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	176,595,974 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	54,736,662 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• calcium ion binding; • GO:0001948 protein binding; • cell adhesion molecule binding;
Cellular component	• integral component of membrane; • spanning component of plasma membrane; • brush border membrane; • cell junction; • cell membrane; • extracellular exosome; • apical plasma membrane; • brush border; • membrane; • cell projection; • microvillus membrane;
Biological process	• cell adhesion; • epithelial cell differentiation; • regulation of microvillus length; • negative regulation of cell growth involved in contact inhibition; • homophilic cell adhesion via plasma membrane adhesion molecules; • cell-cell adhesion mediated by cadherin; • intermicrovillar adhesion; • cell differentiation; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	54825
	268663
	ENSG00000074276
	ENSMUSG00000034918
	Q9BYE9
	E9Q7P9
	NM_001171976; NM_017675
	NM_001033364
	NP_001165447; NP_060145
	NP_001028536
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[5][6][7]

Interactions

PCLKC has been shown to interact with MAST2.[6]

GRCh38: Ensembl release 89: ENSG00000074276 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034918 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
"Entrez Gene: PCLKC protocadherin LKC".

Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma". World J. Gastroenterol. 10 (24): 3569–73. PMID 15534908.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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