PCGF1

PCGF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HPL, 4HPM
Identifiers
Aliases	PCGF1, 2010002K04Rik, NSPC1, RNF3A-2, RNF68, polycomb group ring finger 1
External IDs	OMIM: 610231 MGI: 1917087 HomoloGene: 13090 GeneCards: PCGF1
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	74,507,695 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	83,080,855 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein C-terminus binding; • GO:0001948 protein binding; • metal ion binding; • promoter-specific chromatin binding;
Cellular component	• PcG protein complex; • cell nucleus; • nucleoplasm; • PRC1 complex;
Biological process	• histone H2A monoubiquitination; • transcription, DNA-templated; • regulation of transcription, DNA-templated; • histone H2A-K119 monoubiquitination; • negative regulation of transcription from RNA polymerase II promoter; • chromatin silencing;
	Sources:Amigo / QuickGO
Orthologs
	84759
	69837
	ENSG00000115289
	ENSMUSG00000069678
	Q9BSM1
	Q8R023
	NM_032673
	NM_197992
	NP_116062
	NP_932109
	Wikidata
View/Edit Human	View/Edit Mouse

Polycomb group RING finger protein 1 is a protein that in humans is encoded by the PCGF1 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000115289 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000069678 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nunes M, Blanc I, Maes J, Fellous M, Robert B, McElreavey K (Apr 2001). "NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system". Mech Dev. 102 (1–2): 219–22. doi:10.1016/S0925-4773(01)00288-X. PMID 11287196.
"Entrez Gene: PCGF1 polycomb group ring finger 1".

Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M (2004). "Stem cells and cancer; the polycomb connection". Cell. 118 (4): 409–18. doi:10.1016/j.cell.2004.08.005. PMID 15315754.
Gong Y, Yue J, Wu X, et al. (2007). "NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element". Nucleic Acids Res. 34 (21): 6158–69. doi:10.1093/nar/gkl834. PMC 1693893. PMID 17088287.
Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (2006). "Polycomb Group and SCF Ubiquitin Ligases Are Found in a Novel BCOR Complex That Is Recruited to BCL6 Targets". Mol. Cell. Biol. 26 (18): 6880–9. doi:10.1128/MCB.00630-06. PMC 1592854. PMID 16943429.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gong Y, Wang X, Liu J, et al. (2005). "NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183". FEBS Lett. 579 (1): 115–21. doi:10.1016/j.febslet.2004.11.056. PMID 15620699.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115289 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069678 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11287196-5] Nunes M, Blanc I, Maes J, Fellous M, Robert B, McElreavey K (Apr 2001). "NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system". Mech Dev. 102 (1–2): 219–22. doi:10.1016/S0925-4773(01)00288-X. PMID 11287196.

[entrez-6] "Entrez Gene: PCGF1 polycomb group ring finger 1".

PCGF1

References

Further reading