PAR1 (gene)
Prader-Willi/Angelman region-1, also known as PWAR1, is a human gene.[2] The gene plays a role in posteriorization of follicle cells. They send a signal back to the nucleus of the oocyte after they have received the protein gurken for posteriorization.Par-1 is a serine-threonine kinase and organizes the microtubuli anterior and posterior of the oöcyt.
| PWAR1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | PWAR1, D15S227E, PAR-1, PAR1, Prader Willi/Angelman region RNA 1 | ||||||
| External IDs | OMIM: 600161 GeneCards: PWAR1 | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
| ||||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | [1] | n/a | |||||
| Wikidata | |||||||
| |||||||
References
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: PAR1 Prader-Willi/Angelman region-1".
Further reading
- Sutcliffe JS, Nakao M, Christian S, et al. (1995). "Deletions of a differentially methylated CpG island at the SNRPN gene define a putative imprinting control region". Nat. Genet. 8 (1): 52–8. doi:10.1038/ng0994-52. PMID 7987392.
- Schulze A, Hansen C, Skakkebaek NE, et al. (1996). "Exclusion of SNRPN as a major determinant of Prader-Willi syndrome by a translocation breakpoint". Nat. Genet. 12 (4): 452–4. doi:10.1038/ng0496-452. PMID 8630505.
- Christian SL, Bhatt NK, Martin SA, et al. (1998). "Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11-q13 with average STS spacing of 35 kb". Genome Res. 8 (2): 146–57. doi:10.1101/gr.8.2.146. PMC 310691. PMID 9477342.
- Wirth J, Back E, Hüttenhofer A, et al. (2001). "A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15". Hum. Mol. Genet. 10 (3): 201–10. doi:10.1093/hmg/10.3.201. PMID 11159938.
- Dorsam RT, Tuluc M, Kunapuli SP (2005). "Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets". J. Thromb. Haemost. 2 (5): 804–12. doi:10.1111/j.1538-7836.2004.00692.x. PMID 15099288.
- Nakayama T, Hirano K, Hirano M, et al. (2004). "Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells". Biochem. Pharmacol. 68 (1): 23–32. doi:10.1016/j.bcp.2004.03.005. PMID 15183114.
- Shi X, Gangadharan B, Brass LF, et al. (2005). "Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis". Mol. Cancer Res. 2 (7): 395–402. PMID 15280447.
- Heider I, Schulze B, Oswald E, et al. (2005). "PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism". Oncol. Res. 14 (10): 475–82. PMID 15559761.
- Tantivejkul K, Loberg RD, Mawocha SC, et al. (2005). "PAR1-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism" (PDF). J. Cell. Biochem. 96 (3): 641–52. doi:10.1002/jcb.20533. PMID 16052512.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.