PAAF1

Proteasomal ATPase-associated factor 1 is an enzyme that in humans is encoded by the PAAF1 gene.[3][4][5][6]

PAAF1
Identifiers
AliasesPAAF1, PAAF, Rpn14, WDR71, proteasomal ATPase associated factor 1
External IDsHomoloGene: 49821 GeneCards: PAAF1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.4Start73,876,699 bp[1]
End73,931,124 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80227

n/a

Ensembl

ENSG00000175575

n/a

UniProt

Q9BRP4

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 11: 73.88 – 73.93 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Interactions

PAAF1 has been shown to interact with PSMD10.[7]

References
  1. GRCh38: Ensembl release 89: ENSG00000175575 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Park Y, Hwang YP, Lee JS, Seo SH, Yoon SK, Yoon JB (May 2005). "Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases". Molecular and Cellular Biology. 25 (9): 3842–53. doi:10.1128/MCB.25.9.3842-3853.2005. PMC 1084299. PMID 15831487.
  4. Ponnappan S, Ovaa H, Ponnappan U (Mar 2007). "Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging". The International Journal of Biochemistry & Cell Biology. 39 (4): 799–809. doi:10.1016/j.biocel.2007.01.002. PMID 17317272.
  5. Lassot I, Latreille D, Rousset E, Sourisseau M, Linares LK, Chable-Bessia C, Coux O, Benkirane M, Kiernan RE (Feb 2007). "The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms". Molecular Cell. 25 (3): 369–83. doi:10.1016/j.molcel.2006.12.020. PMID 17289585.
  6. "Entrez Gene: WDR71 WD repeat domain 71".
  7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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