OTUB2

OTUB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TFF, 4FJV
Identifiers
Aliases	OTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDs	OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	94,048,930 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	103,406,350 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• thiol-dependent ubiquitinyl hydrolase activity; • peptidase activity; • cysteine-type peptidase activity; • NEDD8-specific protease activity; • ubiquitin binding; • GO:0001948 protein binding; • hydrolase activity; • thiol-dependent ubiquitin-specific protease activity;
Cellular component	• cell nucleus;
Biological process	• protein deubiquitination; • protein K63-linked deubiquitination; • protein K48-linked deubiquitination; • proteolysis; • protein K11-linked deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	78990
	68149
	ENSG00000089723; ENSG00000277276
	ENSMUSG00000021203
	Q96DC9
	Q9CQX0
	NM_023112
	NM_001177841; NM_026580
	NP_075601
	NP_001171312; NP_080856
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.[5][6]

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[6]

References

ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021203 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
"Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC 1299112. PMID 15258613.
Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome. 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021203 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12704427-5] Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.

[entrez-6] "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

OTUB2

References

Further reading