ONECUT1

ONECUT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDs	OMIM: 604164 MGI: 1196423 HomoloGene: 3309 GeneCards: ONECUT1
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	52,791,078 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	74,891,781 bp[2]
Gene ontology
Molecular function	• DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus;
Biological process	• Notch signaling pathway; • epithelial cell development; • cell differentiation; • cell fate commitment; • endoderm development; • regulation of transcription, DNA-templated; • positive regulation of cell migration; • regulation of transcription from RNA polymerase II promoter; • anatomical structure morphogenesis; • negative regulation of transforming growth factor beta receptor signaling pathway; • spleen development; • transcription from RNA polymerase II promoter; • transcription, DNA-templated; • regulation of cell-matrix adhesion; • glucose metabolic process; • pancreas development; • liver development; • B cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • system development; • endocrine pancreas development; • cilium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3175
	15379
	ENSG00000169856
	ENSMUSG00000043013
	Q9UBC0
	O08755
	NM_004498
	NM_008262
	NP_004489
	NP_032288
	Wikidata
View/Edit Human	View/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [5]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000169856 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043013 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.

ONECUT1

Function

References

Further reading