OAS3

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.[5][6]

OAS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDsOMIM: 603351 MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.13Start112,938,444 bp[1]
End112,973,251 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4940

246727

Ensembl

ENSG00000111331

ENSMUSG00000032661

UniProt

Q9Y6K5

Q8VI93

RefSeq (mRNA)

NM_006187

NM_145226

RefSeq (protein)

NP_006178

NP_660261

Location (UCSC)Chr 12: 112.94 – 112.97 MbChr 5: 120.75 – 120.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligos activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111331 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032661 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
  6. "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9Y6K5 (2'-5'-oligoadenylate synthase 3) at the PDBe-KB.


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