Neuropilin 2

NRP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQJ, 2QQK, 2QQL, 2QQO, 4QDQ, 4QDR, 4QDS, 5DN2
Identifiers
Aliases	NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilin 2
External IDs	OMIM: 602070 MGI: 1100492 HomoloGene: 2875 GeneCards: NRP2
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	205,798,133 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	62,818,695 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• vascular endothelial growth factor-activated receptor activity; • heparin binding; • semaphorin receptor activity; • growth factor binding; • metal ion binding; • cytokine binding; • GO:0001948 protein binding; • identical protein binding; • signaling receptor activity;
Cellular component	• integral component of membrane; • membrane; • cell membrane; • semaphorin receptor complex; • extracellular region; • axon; • glutamatergic synapse; • integral component of postsynaptic membrane;
Biological process	• sympathetic ganglion development; • cell differentiation; • semaphorin-plexin signaling pathway involved in neuron projection guidance; • positive regulation of endothelial cell proliferation; • vascular endothelial growth factor signaling pathway; • nervous system development; • axon guidance; • positive regulation of endothelial cell migration; • multicellular organism development; • sympathetic neuron projection guidance; • vascular endothelial growth factor receptor signaling pathway; • cell adhesion; • angiogenesis; • nerve development; • sympathetic neuron projection extension; • axon extension involved in axon guidance; • outflow tract septum morphogenesis; • neural crest cell migration; • neuron migration; • heart development; • facial nerve structural organization; • vestibulocochlear nerve structural organization; • gonadotrophin-releasing hormone neuronal migration to the hypothalamus; • ventral trunk neural crest cell migration; • negative chemotaxis; • trigeminal ganglion development; • sensory neuron axon guidance; • neural crest cell migration involved in autonomic nervous system development; • facioacoustic ganglion development; • dorsal root ganglion morphogenesis; • cellular response to leukemia inhibitory factor; • regulation of postsynapse organization; • viral process;
	Sources:Amigo / QuickGO
Orthologs
	8828
	18187
	ENSG00000118257
	ENSMUSG00000025969
	O60462
	O35375
NM_003872; NM_018534; NM_201264; NM_201266; NM_201267;
	NM_201279
NM_001077403; NM_001077404; NM_001077405; NM_001077406; NM_001077407;
	NM_010939
NP_003863; NP_061004; NP_957716; NP_957718; NP_957719;
	NP_958436
NP_001070871; NP_001070872; NP_001070873; NP_001070874; NP_001070875;
	NP_035069
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.[5][6]

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.[7]

References

GRCh38: Ensembl release 89: ENSG00000118257 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025969 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (Apr 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250.
Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (Nov 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
"Entrez Gene: NRP2 neuropilin 2".

Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB J. 13 (1): 9–22. PMID 9872925.
Kolodkin AL, Levengood DV, Rowe EG, et al. (1997). "Neuropilin is a semaphorin III receptor". Cell. 90 (4): 753–62. doi:10.1016/S0092-8674(00)80535-8. PMID 9288754.
Giger RJ, Urquhart ER, Gillespie SK, et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron. 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron. 21 (6): 1283–90. doi:10.1016/S0896-6273(00)80648-0. PMID 9883722.
Takahashi T, Nakamura F, Jin Z, et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics. 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
Handa A, Tokunaga T, Tsuchida T, et al. (2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". Int. J. Oncol. 17 (2): 291–5. doi:10.3892/ijo.17.2.291. PMID 10891538.
Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics. 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
Cohen T, Gluzman-Poltorak Z, Brodzky A, et al. (2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
Herzog Y, Kalcheim C, Kahane N, et al. (2002). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mech. Dev. 109 (1): 115–9. doi:10.1016/S0925-4773(01)00518-4. PMID 11677062.
Oh H, Takagi H, Otani A, et al. (2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMC 117569. PMID 11756651.
Fakhari M, Pullirsch D, Abraham D, et al. (2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer. 94 (1): 258–63. doi:10.1002/cncr.10177. PMID 11815985.
Cohen T, Herzog Y, Brodzky A, et al. (2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.
Kawakami T, Tokunaga T, Hatanaka H, et al. (2003). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer. 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118257 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025969 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9529250-5] Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (Apr 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell. 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250.

[pmid9331348-6] Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (Nov 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.

[entrez-7] "Entrez Gene: NRP2 neuropilin 2".

Neuropilin 2

References

Further reading